Review
31 October 2025 / 31 October 2025 by edra
Background. Combination therapy with montelukast and oral antihistamines is commonly used in allergic rhinitis (AR), but its comparative benefit over montelukast monotherapy remains unclear. This meta-analysis aimed to evaluate the efficacy of combination therapy compared to monotherapy, with a focus on symptom-specific outcomes. Methods. A comprehensive search of PubMed, SCOPUS, Embase, Web of Science, and […]
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12 September 2025 / 12 September 2025 by edra
Background. Eosinophilic ascites (EA) is characterised by a high eosinophil count in the ascitic fluid and, although very rare, is mainly caused by eosinophilic gastrointestinal diseases (EGIDs), parasitic infections, and hypereosinophilic syndrome (HES). Symptoms caused by EGIDs are varied and depend on the gastrointestinal tract affected as well as the layer(s) involved; typically, EA implies […]
13 May 2025 / 2 October 2025 by edra
Asthma is a heterogeneous syndrome with a significant social and economic impact. While the knowledge of pheno-endotypes has advanced in severe asthma, little attention has been paid to the phenotypes of mild-moderate asthma. Along this line, a systematic review of the current literature on pollen-induced asthma was carried out, targeting the question whether it can […]
9 May 2025 / 9 May 2025 by edra
Spice allergies are often under-recognized and under-researched, leading to delays in diagnosis and treatment. Cross-reactivity with other plant allergens further complicates accurate diagnosis. This literature review seeks to systematize and analyze current data on hypersensitivity to spices, including pepper, cumin, oregano, anise, mustard, and other seasonings. The review covers research published from 2010 to 2023 […]
7 March 2025 / 24 April 2025 by edra
Chronic rhinosinusitis (CRS) is a complex heterogeneous disease of the nose and paranasal sinuses that presents different phenotypes and endotypes. CRS is a common health problem associated with significant morbidity, as well as with high health care expenditure. As our knowledge on inflammation, tissue remodeling and pathophysiological mechanisms develops, both diagnosis and therapeutic approaches to […]
22 November 2024 / 21 July 2025 by edra
Epithelial barriers are crucial defenses against pathogens and allergens, and recent theories suggest that environmental factors may compromise them, leading to type 2 inflammation and conditions such as asthma, atopic dermatitis, food allergy, and rhinitis. While skin and respiratory barriers show clear dysfunctions in allergies, the role of the gut epithelium is less defined, particularly […]
15 November 2024 / 6 November 2025 by edra
Airways hyperresponsiveness (AHR) is a pathognomonic event of asthma in which the airways are reactive to various bronchoconstrictor stimuli at ‘doses’ that normally have no bronchoconstrictor effect in non-asthmatics. AHR is an objective measure of clinical efficacy, and the introduction of biologics revived interest as a marker of disease and its pathophysiologic mechanism. This article […]
7 November 2024 / 16 May 2025 by edra
The aim of this contribution was to highlight the “favorable” and “unfavorable” roles of domestic and non-domestic animals on airway sensitization processes and on the type/severity of the clinical symptoms induced by their exposure. We performed a literature research in MEDLINE for allergic manifestations and animals. Pets can be “allergy friends” through mechanisms related to […]
25 October 2024 / 17 March 2025 by edra
Many food allergens not actually included in the European priority list of allergenic foods have the potential to cause severe allergic reactions and could escape correct identification and behave as “hidden allergens”. Moreover, the adoption in recent years of novel diets based on plant products and new sustainable foods or the use of specific food […]
26 June 2024 / 10 February 2025 by edra
Background. Food allergy can range from mild to severe, life-threatening reactions with various symptoms and organ involvement. The impact of asthma on severe food-induced allergic reactions is not completely understood. In the hypothesis that asthma increases the risk of severe food-induced allergic reactions, the aim of this study is to compare the incidence of severe […]