Original Article
28 July 2026 / 28 July 2026 by edra
Background. In Southern Europe countries sensitization to both Vespula spp. and Polistes spp. can be observed in 50.5 to 61.5% of anaphylactic sting reactions, hindering the distinction between vespid cross-reactivity and genuine sensitization. CAP-inhibition is regarded as the reference method in such cases. Methods. Retrospective study, including candidates to VIT with double sensitization (skin testing, […]
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28 July 2026 by edra
Background. Quercus ilex is a major contributor to airborne pollen levels in Madrid (central Spain); however, its clinical importance as sensitizer remains unclear. This study aimed to evaluate the prevalence of Q. ilex pollen sensitization, its association with pollen food allergy syndrome (PFAS), and the frequency of sensitization to Que i 1 (PR-10) and Que […]
Background. Hypersensitivity reactions to chemotherapy are increasing, thus there is a need to implement a correct diagnostic pathway to avoid switch to second line therapies or unnecessary drug desensitization. The objective of the study was to evaluate our experience in the management of immediate reactions to chemotherapy, focusing on the role of drug provocation test. […]
23 July 2026 / 28 July 2026 by edra
Background. Iodinated contrast media (ICM) are widely used and generally safe, although hypersensitivity reactions (HSR) may occur. This study aimed to characterize the allergological workup of patients with suspected ICM HSR and evaluate outcomes after re-exposure. Methods. We conducted a unicentric retrospective study of patients referred between January 2012 and December 2024 for suspected ICM […]
25 June 2026 / 25 June 2026 by edra
Background. Recent advancements in hereditary angioedema (HAE) management have focused mainly on long-term prophylaxis (LTP), aiming to achieve total disease control and normalize patients’ lives. The latest international guidelines recommend as first-line options for LTP plasma-derived C1-INH, lanadelumab, and berotralstat. Berotralstat is a highly selective inhibitor of plasma kallikrein and the first licensed oral therapy […]
Background. Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disorder that has been increasingly recognized over recent decades. It is characterized by a type 2 inflammatory response, shared with other type 2 inflammatory conditions such as allergic rhinitis (AR), food allergy (FA), atopic dermatitis (AD), bronchial asthma (BA), and chronic rhinosinusitis with nasal polyps (CRSwNP). […]
10 June 2026 / 10 June 2026 by edra
Background. Permanent tattoos introduce pigments and metal contaminants into the dermis, potentially triggering allergic contact dermatitis (ACD). However, comparative analyses between tattooed and non-tattooed individuals remain limited. This study aimed to assess the impact of tattoos on allergic sensitization and patch test (PT) reactivity. Methods. Retrospective observational analysis of 485 adults undergoing PT at two […]
10 June 2026 / 1 July 2026 by edra
Background. Eosinophilia in hospitalized patients is associated with increased mortality. However, eosinophilia was poorly investigated in the intensive care unit (ICU). The aim of our study was to investigate the prevalence of eosinophilia and its association with clinical outcomes in critically ill patients. Methods. This retrospective cohort study analyzed data from the Russian Intensive Care […]
20 May 2026 / 20 May 2026 by edra
Background. Obesity is associated with worse asthma outcomes, partly due to inflammasome-mediated neutrophilic Type IVc immunity. However, the impact of adiposity on Type IVb airway inflammation remains poorly understood. This study aimed to evaluate the effect of body fat on Type 2 (T2) airway inflammation, measured using fractional exhaled nitric oxide (FeNO). Methods. This community-based […]
23 March 2026 / 23 March 2026 by edra
Background. Cross-reactivity among phylogenetically distant invertebrates—such as mites, crustaceans, and mollusks—is mainly driven by conserved panallergens including tropomyosin, arginine kinase, and troponin C. However, the clinical impact and molecular basis of these cross-reactivities remain incompletely defined. Methods. A multicenter observational study was conducted in 3,777 patients reactive to at least one arthropod or invertebrate allergen […]