Original Article
29 September 2026 by edra
Background. Skin testing is a cornerstone of the diagnostic work-up of Hymenoptera venom allergy. However, evidence comparing high-concentration venom prick testing (Soluprick 300 μg/mL) with others skin prick testing (SPT) and intradermal testing (IDT) remains limited. Methods. In this multicenter retrospective study, 123 consecutive adult patients evaluated for Hymenoptera venom allergy at three tertiary allergy […]
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25 September 2026 by edra
Background. Food allergy (FA) is a growing public health concern among school-aged children. Schools are high-risk settings for accidental exposures and anaphylaxis, yet staff frequently report insufficient preparedness to manage such emergencies. Educational programs are essential to improve knowledge, confidence, and preventive practices. This study aimed to develop and evaluate a nationwide web-based FA training […]
25 September 2026 / 25 September 2026 by edra
Background. Non-specific lipid transfer proteins (nsLTPs) are major plant panallergens in Mediterranean plant-food allergy. In multiplex diagnostics, Pru p 3 reactivity often coexists with pollen-associated nsLTPs, making clinical interpretation difficult. Methods. We analyzed consecutive patients tested with ALEX² between 2021 and 2025. Among 5044 patients, 1271 were reactive to at least one molecule of a […]
24 September 2026 / 24 September 2026 by edra
Background. Peach allergy is a common cause of food allergy in Mediterranean populations, often linked to pollen sensitization. Longitudinal data on peach and inhalant allergen sensitization remain limited, especially in pediatric cohorts. This retrospective study evaluated allergen sensitization patterns in 9,986 patients attending IRCCS San Gerardo dei Tintori, Monza, from 2010 to 2024. Methods. Extract-based […]
28 July 2026 / 28 July 2026 by edra
Background. In Southern Europe countries sensitization to both Vespula spp. and Polistes spp. can be observed in 50.5 to 61.5% of anaphylactic sting reactions, hindering the distinction between vespid cross-reactivity and genuine sensitization. CAP-inhibition is regarded as the reference method in such cases. Methods. Retrospective study, including candidates to VIT with double sensitization (skin testing, […]
28 July 2026 by edra
Background. Quercus ilex is a major contributor to airborne pollen levels in Madrid (central Spain); however, its clinical importance as sensitizer remains unclear. This study aimed to evaluate the prevalence of Q. ilex pollen sensitization, its association with pollen food allergy syndrome (PFAS), and the frequency of sensitization to Que i 1 (PR-10) and Que […]
Background. Hypersensitivity reactions to chemotherapy are increasing, thus there is a need to implement a correct diagnostic pathway to avoid switch to second line therapies or unnecessary drug desensitization. The objective of the study was to evaluate our experience in the management of immediate reactions to chemotherapy, focusing on the role of drug provocation test. […]
23 July 2026 / 28 July 2026 by edra
Background. Iodinated contrast media (ICM) are widely used and generally safe, although hypersensitivity reactions (HSR) may occur. This study aimed to characterize the allergological workup of patients with suspected ICM HSR and evaluate outcomes after re-exposure. Methods. We conducted a unicentric retrospective study of patients referred between January 2012 and December 2024 for suspected ICM […]
25 June 2026 / 25 June 2026 by edra
Background. Recent advancements in hereditary angioedema (HAE) management have focused mainly on long-term prophylaxis (LTP), aiming to achieve total disease control and normalize patients’ lives. The latest international guidelines recommend as first-line options for LTP plasma-derived C1-INH, lanadelumab, and berotralstat. Berotralstat is a highly selective inhibitor of plasma kallikrein and the first licensed oral therapy […]
25 June 2026 / 7 September 2026 by edra
Background. Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disorder that has been increasingly recognized over recent decades. It is characterized by a type 2 inflammatory response, shared with other type 2 inflammatory conditions such as allergic rhinitis (AR), food allergy (FA), atopic dermatitis (AD), bronchial asthma (BA), and chronic rhinosinusitis with nasal polyps (CRSwNP). […]