Original Article
20 October 2026 by edra
Background. Growing evidence suggests that cross-reactivity between penicillins and cephalosporins is mainly driven by R1 side-chain similarity rather than the beta-lactam core. Although cefuroxime, ceftriaxone and cefixime appear to have a low cross-reactivity risk, their use in patients with confirmed penicillin hypersensitivity (HS) remains inconsistent. We aimed to assess the prevalence of HS to cephalosporins […]
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Background. Chronic spontaneous urticaria (CSU) is a common, challenging condition, usually impairs patients’ quality of life. While current medications are mainly symptom-based, many people still suffer. There is limited and inconclusive evidence suggesting a possible role of gluten sensitivity in CSU, and current international guidelines do not recommend a gluten-free diet as a standard therapeutic […]
19 October 2026 by edra
Background. Multiplex diagnostics may identify IgE reactivity without a corresponding phenotype documented at testing. This record-level discordance can reflect incomplete history, limited exposure, cross-recognition, or broader atopy and is not equivalent to asymptomatic sensitisation. We described concordance across six allergen groups and routine-care reassessment of selected Pru p 3/nsLTP and Hymenoptera findings. Methods. We retrospectively […]
29 September 2026 / 19 October 2026 by edra
Background. Skin testing is a cornerstone of the diagnostic work-up of Hymenoptera venom allergy. However, evidence comparing high-concentration venom prick testing (Soluprick 300 μg/mL) with others skin prick testing (SPT) and intradermal testing (IDT) remains limited. Methods. In this multicenter retrospective study, 123 consecutive adult patients evaluated for Hymenoptera venom allergy at three tertiary allergy […]
25 September 2026 by edra
Background. Food allergy (FA) is a growing public health concern among school-aged children. Schools are high-risk settings for accidental exposures and anaphylaxis, yet staff frequently report insufficient preparedness to manage such emergencies. Educational programs are essential to improve knowledge, confidence, and preventive practices. This study aimed to develop and evaluate a nationwide web-based FA training […]
25 September 2026 / 25 September 2026 by edra
Background. Non-specific lipid transfer proteins (nsLTPs) are major plant panallergens in Mediterranean plant-food allergy. In multiplex diagnostics, Pru p 3 reactivity often coexists with pollen-associated nsLTPs, making clinical interpretation difficult. Methods. We analyzed consecutive patients tested with ALEX² between 2021 and 2025. Among 5044 patients, 1271 were reactive to at least one molecule of a […]
24 September 2026 / 24 September 2026 by edra
Background. Peach allergy is a common cause of food allergy in Mediterranean populations, often linked to pollen sensitization. Longitudinal data on peach and inhalant allergen sensitization remain limited, especially in pediatric cohorts. This retrospective study evaluated allergen sensitization patterns in 9,986 patients attending IRCCS San Gerardo dei Tintori, Monza, from 2010 to 2024. Methods. Extract-based […]
28 July 2026 / 28 July 2026 by edra
Background. In Southern Europe countries sensitization to both Vespula spp. and Polistes spp. can be observed in 50.5 to 61.5% of anaphylactic sting reactions, hindering the distinction between vespid cross-reactivity and genuine sensitization. CAP-inhibition is regarded as the reference method in such cases. Methods. Retrospective study, including candidates to VIT with double sensitization (skin testing, […]
28 July 2026 by edra
Background. Quercus ilex is a major contributor to airborne pollen levels in Madrid (central Spain); however, its clinical importance as sensitizer remains unclear. This study aimed to evaluate the prevalence of Q. ilex pollen sensitization, its association with pollen food allergy syndrome (PFAS), and the frequency of sensitization to Que i 1 (PR-10) and Que […]
Background. Hypersensitivity reactions to chemotherapy are increasing, thus there is a need to implement a correct diagnostic pathway to avoid switch to second line therapies or unnecessary drug desensitization. The objective of the study was to evaluate our experience in the management of immediate reactions to chemotherapy, focusing on the role of drug provocation test. […]