Original Article
25 June 2026 / 25 June 2026 by edra
Background. Recent advancements in hereditary angioedema (HAE) management have focused mainly on long-term prophylaxis (LTP), aiming to achieve total disease control and normalize patients’ lives. The latest international guidelines recommend as first-line options for LTP plasma-derived C1-INH, lanadelumab, and berotralstat. Berotralstat is a highly selective inhibitor of plasma kallikrein and the first licensed oral therapy […]
Read more »
Background. Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disorder that has been increasingly recognized over recent decades. It is characterized by a type 2 inflammatory response, shared with other type 2 inflammatory conditions such as allergic rhinitis (AR), food allergy (FA), atopic dermatitis (AD), bronchial asthma (BA), and chronic rhinosinusitis with nasal polyps (CRSwNP). […]
10 June 2026 / 10 June 2026 by edra
Background. Permanent tattoos introduce pigments and metal contaminants into the dermis, potentially triggering allergic contact dermatitis (ACD). However, comparative analyses between tattooed and non-tattooed individuals remain limited. This study aimed to assess the impact of tattoos on allergic sensitization and patch test (PT) reactivity. Methods. Retrospective observational analysis of 485 adults undergoing PT at two […]
10 June 2026 / 1 July 2026 by edra
Background. Eosinophilia in hospitalized patients is associated with increased mortality. However, eosinophilia was poorly investigated in the intensive care unit (ICU). The aim of our study was to investigate the prevalence of eosinophilia and its association with clinical outcomes in critically ill patients. Methods. This retrospective cohort study analyzed data from the Russian Intensive Care […]
20 May 2026 / 20 May 2026 by edra
Background. Obesity is associated with worse asthma outcomes, partly due to inflammasome-mediated neutrophilic Type IVc immunity. However, the impact of adiposity on Type IVb airway inflammation remains poorly understood. This study aimed to evaluate the effect of body fat on Type 2 (T2) airway inflammation, measured using fractional exhaled nitric oxide (FeNO). Methods. This community-based […]
23 March 2026 / 23 March 2026 by edra
Background. Cross-reactivity among phylogenetically distant invertebrates—such as mites, crustaceans, and mollusks—is mainly driven by conserved panallergens including tropomyosin, arginine kinase, and troponin C. However, the clinical impact and molecular basis of these cross-reactivities remain incompletely defined. Methods. A multicenter observational study was conducted in 3,777 patients reactive to at least one arthropod or invertebrate allergen […]
20 March 2026 / 23 March 2026 by edra
Background. The allergic asthma phenotype is the most extensively investigated. However, few studies have explored the association between sensitization to different aeroallergens, asthma severity and blood eosinophil counts, an important biomarker of Type 2 inflammation. This study aims to evaluate associations between sensitization to aeroallergens, severity of asthma, eosinophilic phenotypes and age of onset of […]
20 March 2026 / 20 March 2026 by edra
Background. Tree nut and peanut allergy are common, and often persistent conditions, that significantly affect quality of life. Multiple nut avoidance is common due to cross-reactivity concerns but may cause unnecessary restrictions. Data regarding multiple nut oral food challenges (MN-OFC) remains limited. Our aim was to evaluate the safety and clinical impact of MN-OFC in […]
13 March 2026 / 13 March 2026 by edra
Background. Flaxseed allergy is a rare and potentially underdiagnosed condition. In recent years, sensitization to flaxseed has increased due to its growing presence in the human diet. This study presents three distinct cases of flaxseed allergy and discusses the strengths and limitations of current diagnostic tools in identifying this emerging allergy. Methods. Each case underwent […]
12 March 2026 / 13 March 2026 by edra
Background. Anaphylaxis is the most severe form of acute systemic allergic reactions. Several recommendations have been proposed to guide and standardize anaphylaxis approach and management. The objective of this study is to characterize a cohort of patients referred through an anaphylaxis fast-track system, to enhance and standardize anaphylaxis patient care. Methods. Observational study including patients […]