Review
31 October 2025 / 31 October 2025 by edra
Background. Combination therapy with montelukast and oral antihistamines is commonly used in allergic rhinitis (AR), but its comparative benefit over montelukast monotherapy remains unclear. This meta-analysis aimed to evaluate the efficacy of combination therapy compared to monotherapy, with a focus on symptom-specific outcomes. Methods. A comprehensive search of PubMed, SCOPUS, Embase, Web of Science, and […]
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Original Article
30 October 2025 by edra
Background. Small airway dysfunction (SAD) is increasingly recognized as a key feature in asthma, influencing control, exacerbations, and severity. Spirometry remains the gold standard for lung function assessment but mainly reflects large airways, whereas impulse oscillometry (IOS) offers complementary insights into peripheral airway function. Methods. A retrospective analysis was conducted on 218 patients referred for […]
30 October 2025 / 30 October 2025 by edra
Background. Seed Storage Proteins (SSPs) associate with severe allergic reactions to tree nuts, peanuts, and seeds. This study aimed to characterize the molecular and clinical profiles of SSP sensitization, in patients allergic to peanuts, tree nuts, and/or seeds and sensitized to 2S Albumins (2S) or 7S and 11S Globulins (7S and 11S, respectively). Methods. A […]
10 October 2025 / 10 October 2025 by edra
Background. Triple therapy with inhaled corticosteroids (ICS), long-acting β₂-agonists (LABA), and long-acting muscarinic antagonists (LAMA) is recommended for severe asthma patients with uncontrolled symptoms. Single-inhaler triple therapy (SITT) may offer additional clinical and practical benefits. This study analyzes the clinical profiles of patients receiving LAMA-containing regimens using real-world data from the Italian Registry on Severe […]
Letter to the Editor
9 October 2025 / 9 October 2025 by edra
9 October 2025 by edra
Background. Drug hypersensitivity reactions (DHRs) include allergic, exaggerated pharmacologic, and pseudoallergic reactions to medications. The basophil activation test (BAT) using CD63 expression is a sensitive and specific complementary tool in the diagnosis of immediate DHRs. Methods. In this study we analysed retrospectively 1160 patients with history of DHRs categorized into several subgroups of diagnoses. BAT […]
15 September 2025 / 15 September 2025 by edra
12 September 2025 / 12 September 2025 by edra
Background. Eosinophilic ascites (EA) is characterised by a high eosinophil count in the ascitic fluid and, although very rare, is mainly caused by eosinophilic gastrointestinal diseases (EGIDs), parasitic infections, and hypereosinophilic syndrome (HES). Symptoms caused by EGIDs are varied and depend on the gastrointestinal tract affected as well as the layer(s) involved; typically, EA implies […]
Editorial
4 September 2025 / 9 September 2025 by edra