A clinical update on chronic rhinosinusitis and nasal polyposis
Show more: Authors information and Publication history
Authors Information
1Department of Allergy and Clinical Immunology, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de
Coimbra, Coimbra, Portugal
2Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
3Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
4CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
5SOtorhinolaryngology Service, Centro Hospitalar de Lisboa Central, São José Local Health Unit, Lisbon, Portugal
6Otorhinolaryngology Service, Hospital da Luz, Lisbon, Portugal
7Department of Allergy and Clinical Immunology, São João Hospital, São João Local Health Unit, Porto, Portugal
8Immunology and Allergology Service, Gaia and Espinho Local Health Unit, Vila Nova de Gaia, Portugal
History
Published: 24 April 2025
Accepted: 11 February 2024
Received: 08 September 2024
SUMMARY
Chronic rhinosinusitis (CRS) is a complex heterogeneous disease of the nose and paranasal sinuses that presents different phenotypes and endotypes. CRS is a common health problem associated with significant morbidity, as well as with high health care expenditure. As our knowledge on inflammation, tissue remodeling and pathophysiological mechanisms develops, both diagnosis and therapeutic approaches to CRS improve. This review outlines key drivers in the pathogenesis of CRS with and without nasal polyps, current diagnostic tools clinicians can rely on in clinical practice, and current and future treatment options, while providing a general overview of up-to-date guidelines for CRS diagnosis and management. A better understanding of CRS can pave the way for the optimization and development of novel therapies, benefiting patients who suffer with more severe phenotypes and allowing a personalized approach to the disease.
