A clinical update on chronic rhinosinusitis and nasal polyposis
Show more: Authors information and Publication history
Authors Information
1Allergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal
2Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
3Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
4CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
5Serviço de Otorrinolaringologia, Centro Hospitalar de Lisboa Central, Unidade Local de Saúde de São José, Lisbon, Portugal
6Serviço de Otorrinolaringologia, Hospital da Luz, Lisbon, Portugal
7Serviço de Imunoalergologia, Hospital de São João, Unidade Local de Saúde de S. João, Porto, Portugal
8Serviço de Imunoalergologia, Unidade Local de Saúde de Gaia e Espinho, Vila Nova de Gaia, Portugal
History
Published: 24 April 2025
Accepted: 11 February 2024
Received: 08 September 2024
SUMMARY
Chronic rhinosinusitis (CRS) is a complex heterogeneous disease of the nose and paranasal sinuses that presents different phenotypes and endotypes. CRS is a common health problem associated with significant morbidity, as well as with high health care expenditure. As our knowledge on inflammation, tissue remodeling and pathophysiological mechanisms develops, both diagnosis and therapeutic approaches to CRS improve. This review outlines key drivers in the pathogenesis of CRS with and without nasal polyps, current diagnostic tools clinicians can rely on in clinical practice, and current and future treatment options, while providing a general overview of up-to-date guidelines for CRS diagnosis and management. A better understanding of CRS can pave the way for the optimization and development of novel therapies, benefiting patients who suffer with more severe phenotypes and allowing a personalized approach to the disease.
