Review
15 May 2014 / 17 April 2024 by almaware
Currently, sublingual immunotherapy (SLIT) may be performed by a number of allergen extract in different preparations but in a near future only products fulfilling the requirements from the regulatory agencies, that make mandatory a pharmaceutical quality, will be authorized. Indeed, two products with such characteristics are already available for SLIT in grass pollen allergic patients, Grazax® […]
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Work-related asthma, encompassing both occupational asthma and work-exacerbated asthma, accounts for 10%-25% of adult asthma in Europe and occupational asthma is currently one of the most common forms of occupational lung disease in many industrialized countries. It is cause of direct and indirect costs for the worker, the employer and the society and it is […]
9 May 2014 / 17 April 2024 by almaware
Allergen-specific IgG antibodies play a significant role in allergen-specific tolerance, either naturally induced or generated by specific immunotherapy. Nevertheless, the underlying mechanisms are still debated, and allergen-specific IgG determinations are not recommended as a diagnostic tool in IgE-mediated allergy. This review summarizes the latest findings on the immunological and diagnostic role of IgG antibodies in […]
The Component Resolved Diagnostic (CRD) approach has been developed when highly purified or recombinant allergen molecules have become available. These molecules are the allergenic proteins toward which the specific and clinically relevant IgE immune response is directed. So, the identification of protein families and cross-reactivity patterns of importance in allergy have been possible. The Italian […]
Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH) is a rare, autosomal-dominant disease. HAE-C1-INH is characterized by recurrent attacks of marked, diffuse, nonpitting and nonpruritic skin swellings, painful abdominal attacks, and laryngeal edema. The extremities and the gastrointestinal tract are most commonly affected.Swelling of the upper respiratory mucosa poses the greatest risk because death from asphyxiation […]
PubMed databases were searched for articles regarding asthma phenotypes. Asthma has long been recognized as a heterogeneous disease, with hallmark features including age of onset, pattern of severity and other clinical characteristics, but recently it is no longer considered as single disease but rather as a series of complex, overlapping individual phenotypes, and a novel […]