Review
2 January 2023 / 17 April 2024 by almaware
The autologous serum skin test (ASST) has been used in patients with chronic spontaneous urticaria (CSU) as a means to detect an auto reactivity state forthirty-five years now. Nonetheless, several aspects of this old diagnostic test are still insufficiently defined. Particularly, the nature of the factor(s) responsible for the appearance of the wheal-and-flare skin reaction […]
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27 October 2022 / 17 April 2024 by almaware
It is currently recognized that the airway epithelium plays a pivotal role in orchestrating inflammatory, immune, and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. The impact of pollen on respiratory epithelium is multifaceted and goes beyond the direct barrier damage driven by the best-known Type-2 response. After pollen-driven activation, […]
2 August 2022 / 23 May 2024 by almaware
Background. Based on the cross-reactivity between pollen lipid transfer proteins (LTPs) and the peach LTP, Pru p 3, it has been suggested that the pollen might initiate the LTP sensitization process. Objective. To establish whether LTP allergy can be considered as a pollen-food syndrome. Methods. The literature was reviewed and new data of component-resolved diagnosis from Italy obtained by both […]
28 June 2022 / 17 April 2024 by almaware
3 May 2022 / 17 April 2024 by almaware
Anaphylaxis is the most severe systemic hypersensitivity reaction, it can be caused by a number of well identified triggers such as foods, drugs, stinging insects and facilitated by predisposing clinical conditions. However, sometimes anaphylaxis shows up with uncommon or peculiar characteristics which could delay diagnosis and therapeutic treatment. In this report we aimed to describe […]
24 February 2022 / 17 April 2024 by almaware
Allergic rhinitis (AR) is a common disease affecting up to 40% of the general population worldwide. In the Coronavirus 2019 (COVID-19) pandemic era, many observational studies analysing the effect of asthma and chronic obstructive pulmonary disease on the risk of developing COVID-19 were conducted, while data on AR are limited.In this paper, we review the […]
3 January 2022 / 17 April 2024 by almaware
Studies evaluating the association of Interleukin 10 (IL-10) polymorphisms withrisk of pediatric asthma found inconsistent data. Here, we performed a meta-analysisto get a precise estimation of the associations. Relevant studies identified in thePubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of23 case-control studies including nine studies with 1298 cases and 1079 […]
26 October 2021 / 13 May 2024 by almaware
Adolescence is one of the most rapid phases of human development, in which biological maturity precedes psychosocial maturity. Rhinoconjunctivitis (ARC) is present in around 15% of 13-14-year-old children, which indicates a higher prevalence when compared with 6-7-year-old children (8.5%). During childhood (0- 10 years) prevalence of allergic rhinitis (AR) is higher among males compared to females. […]
9 September 2021 / 17 April 2024 by almaware
T cells are coordinators of the immune response and have been shown to play a central role in the pathophysiology of asthma. A good understanding of the T cells functions in asthma is important for therapeutic reasons, in particular for the choice of biological treatments in severe asthma. Although classically considered a Th2 disease, it […]
21 June 2021 / 17 April 2024 by almaware
T helper 17 (Th17) are a CD4+ T subpopulation cells which are involved in the host protection against microbes such as extracellular and intracellular bacteria, parasites, fungi, and viruses. Monogenic defects including those mutations in some genes such as the signal transducer and activator of transcription (STAT)1 and 3, dedicator of cytokinesis 8 (DOCK8), autoimmune regulator […]