Original Article
28 May 2014 / 17 April 2024 by almaware
Background: In multiple NSAID reactors, intolerance to weak COX-1 inhibitors may pose relevant therapeutic problems when painful, febrile or rheumatic disorders co-exist. Objective: To assess whether pre-medication with a second generation antihistamine is able to prevent urticaria induced by “alternative” NSAIDs. Methods: 87 with a history of urticaria following the administration of multiple, chemically unrelated […]
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Background: The worldwide prevalence of allergic diseases such as rhinitis, asthma, and atopic dermatitis is continuously increasing, while other allergic disorders such as urticaria and angioedema are less investigated.We performed a population study evaluating the prevalence of any kind of allergic disorders. Methods: The entire population of 7,201 inhabitants of Cotignola (Ravenna, Italy) was surveyed […]
Childhood asthma presents with specific clinical and functional characteristics. The aim of our study was the description of a large cohort of asthmatic children. It was also to assess their outcome with maintenance therapy according to guidelines, and to analyze the relationship with baseline’s characteristics.We focused particularly on clinical and functional pediatric specificities. Methods: Prospective […]
Background: Inhaled combined therapy improves the pulmonary function in asthmatic patients. The effect on the airway hyperresponsiveness (AHR) and the efficacy of different pharmacological schedules is not well clarified on adolescent asthmatics. Objective: Evaluate the responses to different combined inhaled therapies in adolescent asthmatics and study its impact on exercise induced AHR. Methods: Basal lung […]
Background: Lipid transfer proteins (LTP) are pan-allergens in plant derived foods that have been also detected in several pollens. The observed cross-reactivity between pollen and plant-food LTPs has led to hypothesize that primary sensitisation to this allergen may occur through the airways. Objective: The present study looked at the prevalence of hypersensitivity to different LTP-containing […]
Background: specific oral tolerance induction (SOTI) is a promising approach in the treatment of severe food allergies. Different protocols have demonstrated its efficacy. Nevertheless, SOTI is still considered an experimental method and should be limited to highly controlled settings. Aims: to define the incidence and severity of adverse reactions, possible risk factors, and the safety […]
25 May 2014 / 17 April 2024 by almaware
Background: Lipid transfer protein (LTP) is a widely cross-reacting plant pan-allergen, and sensitized patients may react to many foods. Although peanut allergy is frequently reported by LTP-allergic patients, the evidence of the presence of an allergen homologous to LTP in peanuts is limited. Objective: To assess the prevalence of peanut allergy in patients sensitized to […]
Background: Natural rubber latex allergy is a condition at high risk of anaphylaxis during surgery. However, latex contains several protein allergens and not all of them may show the same clinical relevance. Objective: To investigate the clinical relevance of Hev b 8, the natural rubber latex profilin. Methods: Seven patients without a clinical history of […]
20 May 2014 / 17 April 2024 by almaware
Background: Statins are serum cholesterol-lowering agents used for the prevention and treatment of atherosclerotic vascular disease. There is, however, growing evidence that statins have immunomodulatory and anti-inflammatory activities and may prove invaluable in the treatment of immunological and inflammatory disorders. Objective: On these basis we evaluated the effect of statins on the proliferation of fibroblasts […]
Celiac disease (CD) is a chronic inflammatory enteropathy of the small bowel resulting from a local TH1-mediated reaction to wheat gliadins and barley, rye and oat prolamins with the development of auto-antibodies to transglutaminases. As well as for other chronic inflammatory diseases, genetic background and environmental factors participate to pathogenesis. An increased traffic of CD34+ […]