Original Article
28 May 2014 / 17 April 2024 by almaware
Background: food challenge is required to assess tolerance in cow milk (CM) allergy. A positive challenge contraindicates the reintroduction of CM. Specific oral tolerance induction (SOTI) is a promising treatment. Methods: all children admitted for a challenge were prospectively enrolled. To those tolerating between 2 and 150 ml a SOTI protocol was offered. Outcome, adverse […]
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The definition of reference normal values for urinary LTE4 still represents an open question. Aim: to assess the influence of gender and age on urinary LTE4 levels in normal individuals. Methods: after their informed consent, urinary LTE4 was measured in 124 well matched, non smoker, non atopic subjects (mean age 49.5 y±20.1 sd; range 4-85 […]
Background: Allergy to crustacean shellfish is one of the most common IgE-mediated food allergies, and tropomyosin has been identified as the major allergen. However, not all subjects affected by this allergy are IgE-positive to tropomyosin. Aims: To evaluate whether sera of patients with shrimp allergy but negative for tropomyosin react to other allergen(s); and to […]
Objective: Omalizumab (OM), an innovative biological treatment for difficult asthma with perennial sensitisations, is an humanized monoclonal anti-IgE antibody that binds free circulating IgE; inhibits mast cell and basophil activation by combining free IgE, leads to IgE receptor down-regulation, thus blocking the inflammatory cascade. AIM of the study was to assess real-world cost-utility of add-on […]
Background: Epinephrine is the treatment of choice for acute food-allergic reactions but existing guidelines state that it should be prescribed uniquely to patients who already experienced at least one food-induced anaphylactic episode. Objective: We investigated whether in Italy epinephrine auto-injector is prescribed uniquely following the existing guidelines only, or is allergen-informed as well (i.e., based […]
Background: The allergenic profile of patients hypersensitive to pollen pan-allergens, profilin and polcalcin, has received little attention so far. Objective: To detect whether hypersensitivity to profilin and polcalcin follows sensitization to specific allergen sources or represents a primary phenomenon, and to examine the sensitization profiles of patients hypersensitive to pollen pan-allergens. Methods: IgE reactivity to […]
Background: Foods containing flaxseed proteins rich in polyunsaturated fatty acids are new on the market. Objectives: In a population of patients attending the allergology department, we evaluated the frequency of sensitization to flaxseed, characterized allergens and looked for modifications related to industrial processing. Methods: Natural, heated and extruded flaxseeds were tested using prick-in-prick tests (PIP […]
Background: Olive pollen sensitization is surprisingly frequent in Milan, an area that is virtually both olive- and ash-free.Objective:To establish the prevalence of olive pollen sensitization north of Milan, and to investigate the allergens involved.Methods: 300 pollenallergic patients living in this area were randomly selected. Based on SPT-results, olive pollen reactors were classified as multi-sensitized, oligo-sensitized, […]
The standardization of allergen extracts is of primary relevance to the clinical efficacy. Biological standardization procedures are widely used in the commercial production of vaccines. We tested, in grass-allergic patients, the potency of three different grass extracts for sublingual immunotherapy by means of skin prick tests. Specific IgE against Phl p 1, 2, 4, 5, […]
Background: Studies suggest a link between vitamin D deficiency and development of asthma and allergic diseases. Aim: To determine a) the association between vitamin D and asthma among children , b) difference in level of vitamin D in asthmatic children and control, and c) effect of vitamin D on atopy markers. Setting: Case-control study done, […]