Original Article
28 May 2014 / 17 April 2024 by almaware
Background: Carboxymethylcellulose (CMC) is used extensively in the pharmaceutical and food industries on account of its various properties. Anaphylactic reactions are rare. It has been reported principally after intra-articular infiltration of sustained-release corticosteroids containing CMC and, very rarely, after barium enema. Methods: A case of pre-lethal anaphylactic shock after barium enema was studied by prick-test, […]
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The efficacy and safety of monomeric allergoid (Lofarma, Milan) have been demonstrated in adults but very few studies have examined it in children. This study therefore investigated the efficacy and safety of this sublingual immunotherapy (SLIT) at the dosage of 1000 AU five times a week without any up-dosing. Forty allergic children(17 M and 23 […]
Background: There is some evidence suggesting that factors other than autoantibodies to FceRI or IgE and histamine released from mast cells may play a role in skin autoreactivity that characterizes many patients with chronic urticaria (CU) and, possibly, in the pathogenesis of this disease. Objective: The effect of antihistamine treatment on autologous plasma skin test (APST) […]
Background: Allergy to crustacean shellfish is one of the most common IgE-mediated food allergies, and tropomyosin has been identified as the major allergen. However, not all subjects affected by this allergy are IgE-positive to tropomyosin. Aims: To evaluate whether sera of patients with shrimp allergy but negative for tropomyosin react to other allergen(s); and to […]
Objective: Omalizumab (OM), an innovative biological treatment for difficult asthma with perennial sensitisations, is an humanized monoclonal anti-IgE antibody that binds free circulating IgE; inhibits mast cell and basophil activation by combining free IgE, leads to IgE receptor down-regulation, thus blocking the inflammatory cascade. AIM of the study was to assess real-world cost-utility of add-on […]
Background: Epinephrine is the treatment of choice for acute food-allergic reactions but existing guidelines state that it should be prescribed uniquely to patients who already experienced at least one food-induced anaphylactic episode. Objective: We investigated whether in Italy epinephrine auto-injector is prescribed uniquely following the existing guidelines only, or is allergen-informed as well (i.e., based […]
Background: The allergenic profile of patients hypersensitive to pollen pan-allergens, profilin and polcalcin, has received little attention so far. Objective: To detect whether hypersensitivity to profilin and polcalcin follows sensitization to specific allergen sources or represents a primary phenomenon, and to examine the sensitization profiles of patients hypersensitive to pollen pan-allergens. Methods: IgE reactivity to […]
Background: Foods containing flaxseed proteins rich in polyunsaturated fatty acids are new on the market. Objectives: In a population of patients attending the allergology department, we evaluated the frequency of sensitization to flaxseed, characterized allergens and looked for modifications related to industrial processing. Methods: Natural, heated and extruded flaxseeds were tested using prick-in-prick tests (PIP […]
Background: Olive pollen sensitization is surprisingly frequent in Milan, an area that is virtually both olive- and ash-free.Objective:To establish the prevalence of olive pollen sensitization north of Milan, and to investigate the allergens involved.Methods: 300 pollenallergic patients living in this area were randomly selected. Based on SPT-results, olive pollen reactors were classified as multi-sensitized, oligo-sensitized, […]
The standardization of allergen extracts is of primary relevance to the clinical efficacy. Biological standardization procedures are widely used in the commercial production of vaccines. We tested, in grass-allergic patients, the potency of three different grass extracts for sublingual immunotherapy by means of skin prick tests. Specific IgE against Phl p 1, 2, 4, 5, […]