Case Report
16 May 2014 / 17 April 2024 by almaware
We present a case of acute generalized exanthematous pustolosis (AGEP) induced by amoxicillin-clavulanate. Clinical diagnosis was confirmed by symptoms presentation and histological features (Euroscar score point compatible with definite diagnosis).Patch testing performer six months later confirmed sensitization to the culprit drug and showed positivity also to other beta-lactam antibiotics (penicillin G and cephalexin). We believe […]
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Multiple sclerosis is a disease with a potentially severe prognosis and epidemiologically increasing. Interferon beta 1a is a very useful maintenance therapy widely used by neurologists. In the literature, there are several case reports of hypersensitivity reactions. In this case report we describe an anaphylactic IgE mediated reaction to interferon beta 1a. We also describe, […]
Food protein-induced enterocolitis syndrome (FPIES) is a potentially severe non-IgEmediated food allergy usually caused by cow’s milk or soy, and more rarely by solid foods such as rice, oats, barley, chicken, turkey, egg white, green peas and peanuts. In children with FPIES, the presence of specific IgE antibodies to the causative food, either at presentation […]
Type I hypersensitivity reactions have been described after solid organ transplantation despite T cell targeted immunosuppressive therapy.There are several reports of food allergy, asthma and eosinophilic colitis in pediatric transplant recipients under Tacrolimus immunosuppression, but not Cyclosporine A. We present the case of a 6 year old patient that developed de novo atopic dermatitis, eosinophilia […]
Many conditions may present as angioedema. We report a case of a 46 year-old man presenting with intermittent episodes of penile swelling. Following a series of investigations, he was diagnosed with genital granulomatosis. Ano-genital granulomatosis is a rare chronic inflammatory condition and that can present as diffuse penile, scrotal, vulvar or ano-perineal swelling with non-caseating […]
This study reports an unusual case of repeated anaphylactic episodes to orange and apple without clinical evidence of primary sensitization to peach LTP. In vitro and in vivo tests revealed heat stability of the implicated allergens and also provided new evidence of differences in allergenicity among apple varieties and strong cross reactivity of citrus fruits. […]
15 May 2014 / 17 April 2024 by almaware
Mastocytosis is a clonal disease derived from hematopoietic bone marrow progenitor cells.Clinical manifestations of the disease vary greatly depending on tissue involvement. Omalizumab is a recombinant humanized monoclonal anti-IgE antibody licensed in the treatment of asthma with increasing reports of clinical efficiency in other allergic diseases. We describe a case of a patient with mastocytosis […]
Specific oral tolerance induction to food (SOTI) is a new promising treatment for persistent IgE-mediated food allergy.Our paper reports a case of a 5-year-old girl with cow’s milk allergy, who developed severe anaphylaxis after the ingestion of a croissant containing sheep’s milk ricotta cheese, even though she had been previously desensitized to cow’s milk through […]
Food protein-induced enterocolitis syndrome is a non-IgE-mediated food allergy that typically occurs within the first year of age and it is often misdiagnosed for its rarity.This syndrome is usually caused by milk or soy in formula-fed infants, but it can also be associated to solid food proteins, fruit proteins included.We describe and discuss the first […]
9 May 2014 / 17 April 2024 by almaware
We described the first case reported in literature of anaphylactic shock after administration of pollen extract vaccine chemically modified (allergoid) adsorbed onto L-Tyrosine depot adjuvanted with monophosphoryl lipid A (Pollinex® Quattro MPL-4).