Original Article
9 October 2025 by edra
Background. Drug hypersensitivity reactions (DHRs) include allergic, exaggerated pharmacologic, and pseudoallergic reactions to medications. The basophil activation test (BAT) using CD63 expression is a sensitive and specific complementary tool in the diagnosis of immediate DHRs. Methods. In this study we analysed retrospectively 1160 patients with history of DHRs categorized into several subgroups of diagnoses. BAT […]
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Letter to the Editor
15 September 2025 / 15 September 2025 by edra
Review
12 September 2025 / 12 September 2025 by edra
Background. Eosinophilic ascites (EA) is characterised by a high eosinophil count in the ascitic fluid and, although very rare, is mainly caused by eosinophilic gastrointestinal diseases (EGIDs), parasitic infections, and hypereosinophilic syndrome (HES). Symptoms caused by EGIDs are varied and depend on the gastrointestinal tract affected as well as the layer(s) involved; typically, EA implies […]
Editorial
4 September 2025 / 9 September 2025 by edra
3 September 2025 by edra
Background. Chronic spontaneous urticaria (CSU) is a common disorder characterized by the recurrence of wheals and/or angioedema for more than 6 weeks. About 35% of patients experience wheals and angioedema (AE-CSU) and around 6% of patients only present angioedema, also known as chronic histaminergic angioedema (CHA). As few data comparing CHA and AE-CSU are published, […]
3 September 2025 / 3 September 2025 by edra
Position Paper
2 September 2025 / 11 September 2025 by edra
Evidence supports the hypothesis of pollen-induced asthma as a specific asthma phenotype, with defined clinical features and tailored pathways for its clinical management. The probability of diagnosis varies significantly in the pollen season, in which allergic patients are symptomatic, as compared to asymptomatic periods outside the pollen season. In this context, a novel diagnostic scheme […]
3 July 2025 / 3 July 2025 by edra
Background. Clinical and laboratory features of wheat allergy dependent on augmentation factor (WALDA) are scarcely characterised as compared to wheat anaphylaxis dependent on augmentation factor (WANDA). In this study we assessed the pattern of comorbid atopic and gastrointestinal diseases and the sensitisation profile in patients with WALDA presenting with intermittent urticaria. Methods. We retrospectively assessed […]
3 July 2025 by edra
2 July 2025 by edra
HAE is a rare disease manifesting with recurrent attacks of disabling and potentially life-threatening angioedema for which early diagnosis and effective therapy are critical. Recent scientific progress and the development of novel therapeutic options has engendered multiple important changes in the diagnosis and management of the disease. In an attempt to encourage and facilitate the […]