2.6
2023

Consensus on diagnosis and management of hereditary angioedema in Greece

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Authors Information

1Department of Immunology & Histocompatibility, School of Medicine, University of Thessaly, Thessaly, Greece

2Department of Allergology-Clinical Immunology, Laikon General Hospital of Athens, Athens, Greece

3Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Greece

4Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece

5Department of Allergy, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece

6Allergy Outpatient Clinic, 401 General Military Hospital of Athens, Athens, Greece

7Allergologist

8First Department of Pediatrics, Ippokration General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

9Department of Allergology, Naval Hospital of Athens, Athens, Greece

History

Published: 02 July 2025
Accepted: 04 June 2025
Received: 06 December 2024

SUMMARY

HAE is a rare disease manifesting with recurrent attacks of disabling and potentially life-threatening angioedema for which early diagnosis and effective therapy are critical. Recent scientific progress and the development of novel therapeutic options has engendered multiple important changes in the diagnosis and management of the disease. In an attempt to encourage and facilitate the use of this progress for all patients, the Hellenic Society of Angioedema has undertaken the effort to develop consensus recommendations for the diagnosis, treatment and management of hereditary angioedema in special patients’ groups. To this aim a panel of 11 experts was assembled and a modified Delphi method was used. After a comprehensive review of relevant literature from the last five years retrieved from Medline, the initial text of the recommendations was formulated and consensus was sought among the experts. The consensus included statements that were agreed by more than 80% of the experts. This article presents the 24 consensus recommendations that were finally formulated.

KEY WORDS
C1-esterase inhibitor deficiency; hereditary angioedema; recommendations; short-term prophylaxis; unknown hereditary angioedema.

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European Annals of Allergy and Clinical Immunology ISSN 1764-1489 | © 2024