Original Article
16 January 2026 / 16 January 2026 by edra
Background. Oral immunotherapy (OIT) is a promising strategy for severe and persistent cow’s milk (CM) allergy. However, clinical experience concerning long-term follow-up is scarce. The objective is to assess long-term efficacy and safety of maintenance phase of OIT in real-life. Methods. Prospective study of children with severe IgE-mediated CM allergy that underwent CM-OIT, and were […]
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15 January 2026 / 15 January 2026 by edra
Background. Soy allergy represents a diagnostic challenge, particularly when mediated by Gly m 4, a PR-10 protein known for its cross-reactivity with birch pollen allergens. Traditional diagnostic methods, including skin prick tests (SPTs) and specific IgE assays, often lack sensitivity or specificity, especially for Gly m 4-mediated allergies. Methods. In this study, the basophil activation […]
Letter to the Editor
Commentary
Comment on: Demographic and clinical characteristics of chronic histaminergic angioedema and chronic urticaria with angioedema, a multicenter Italian experience – doi: 10.23822/EurAnnACI.1764-1489.411
Review
31 October 2025 / 31 October 2025 by edra
Background. Combination therapy with montelukast and oral antihistamines is commonly used in allergic rhinitis (AR), but its comparative benefit over montelukast monotherapy remains unclear. This meta-analysis aimed to evaluate the efficacy of combination therapy compared to monotherapy, with a focus on symptom-specific outcomes. Methods. A comprehensive search of PubMed, SCOPUS, Embase, Web of Science, and […]
30 October 2025 / 15 January 2026 by edra
Background. Small airway dysfunction (SAD) is increasingly recognized as a key feature in asthma, influencing control, exacerbations, and severity. Spirometry remains the gold standard for lung function assessment but mainly reflects large airways, whereas impulse oscillometry (IOS) offers complementary insights into peripheral airway function. Methods. A retrospective analysis was conducted on 218 patients referred for […]
30 October 2025 / 30 October 2025 by edra
Background. Seed Storage Proteins (SSPs) associate with severe allergic reactions to tree nuts, peanuts, and seeds. This study aimed to characterize the molecular and clinical profiles of SSP sensitization, in patients allergic to peanuts, tree nuts, and/or seeds and sensitized to 2S Albumins (2S) or 7S and 11S Globulins (7S and 11S, respectively). Methods. A […]
10 October 2025 / 10 October 2025 by edra
Background. Triple therapy with inhaled corticosteroids (ICS), long-acting β₂-agonists (LABA), and long-acting muscarinic antagonists (LAMA) is recommended for severe asthma patients with uncontrolled symptoms. Single-inhaler triple therapy (SITT) may offer additional clinical and practical benefits. This study analyzes the clinical profiles of patients receiving LAMA-containing regimens using real-world data from the Italian Registry on Severe […]
9 October 2025 / 9 October 2025 by edra