Original Article
23 March 2026 / 23 March 2026 by edra
Background. Cross-reactivity among phylogenetically distant invertebrates—such as mites, crustaceans, and mollusks—is mainly driven by conserved panallergens including tropomyosin, arginine kinase, and troponin C. However, the clinical impact and molecular basis of these cross-reactivities remain incompletely defined. Methods. A multicenter observational study was conducted in 3,777 patients reactive to at least one arthropod or invertebrate allergen […]
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20 March 2026 / 23 March 2026 by edra
Background. The allergic asthma phenotype is the most extensively investigated. However, few studies have explored the association between sensitization to different aeroallergens, asthma severity and blood eosinophil counts, an important biomarker of Type 2 inflammation. This study aims to evaluate associations between sensitization to aeroallergens, severity of asthma, eosinophilic phenotypes and age of onset of […]
20 March 2026 / 20 March 2026 by edra
Background. Tree nut and peanut allergy are common, and often persistent conditions, that significantly affect quality of life. Multiple nut avoidance is common due to cross-reactivity concerns but may cause unnecessary restrictions. Data regarding multiple nut oral food challenges (MN-OFC) remains limited. Our aim was to evaluate the safety and clinical impact of MN-OFC in […]
Letter to the Editor
18 March 2026 / 18 March 2026 by edra
Review
13 March 2026 / 18 March 2026 by edra
Long-lived plasma cells (LLPCs) constitute a specialized and durable arm of humoral memory. While their role in maintaining long-term IgG and IgA immunity is firmly established, their contribution to IgE-mediated allergic disease remains clinically unproven. Nevertheless, recent advances in LLPC biology—accelerated substantially since 2021—have shown that IgE⁺ LLPC-like cells do exist in human bone marrow […]
13 March 2026 / 13 March 2026 by edra
Background. Flaxseed allergy is a rare and potentially underdiagnosed condition. In recent years, sensitization to flaxseed has increased due to its growing presence in the human diet. This study presents three distinct cases of flaxseed allergy and discusses the strengths and limitations of current diagnostic tools in identifying this emerging allergy. Methods. Each case underwent […]
12 March 2026 / 13 March 2026 by edra
Background. Anaphylaxis is the most severe form of acute systemic allergic reactions. Several recommendations have been proposed to guide and standardize anaphylaxis approach and management. The objective of this study is to characterize a cohort of patients referred through an anaphylaxis fast-track system, to enhance and standardize anaphylaxis patient care. Methods. Observational study including patients […]
12 March 2026 by edra
Background. Hereditary angioedema (HAE) is a rare genetic disorder with variable prevalence, characterized by recurrent swelling in various parts of the body, including potential laryngeal attacks, significantly affecting patients’ quality of life. Methods. A nationwide, cross-sectional survey study was conducted between December 2023 and June 2024, targeting adults (aged 18 and older). The patients filled […]
Background. The diagnosis of immediate drug allergy (DA) relies on a combination of skin tests (ST), drug provocation tests (DPT), specific IgE levels (sIgE) and/or basophil activation tests (BAT). We aimed to compare BAT results with those of other allergy tests in patients with suspected immediate DA to a heterogeneous group of drugs, aiming to […]
12 March 2026 / 12 March 2026 by edra