Prevalence, molecular characterization, and clinical relevance of sensitization to Anisakis simplex in children with sensitization and/or allergy to Dermatophagoides pteronyssinus

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Authors Information

1 Primary Care Pediatrics, ASL Salerno, Vietri sul Mare, Italy
2 Department of Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy
3 Primary Care Pediatrics, ASL BN1, Benevento, Italy
4 Ismea, Istituto di Servizi per il Mercato Agricolo Alimentare, Rome, Italy
5 Department of Paediatrics, Fatebenefratelli Hospital, Benevento, Italy


Published online: 2 November 2017
Accepted: 29 May 2017
Received: 22 April 2017


Prevalence of the Anisakis Simplex‘s (AS) sensitization in children sensitized to Dermatophagoides pteronissynus (DP) is not known, neither it is to which percentage it might be due to cross-reactivity. The primary objective of the present retrospective cross-sectional study is to evaluate the prevalence of sensitization to AS in children sensitized or allergic to DP. Secondary outcomes were the prevalence of cross-reactivity and clinical relevance of the condition. The prevalence of sensitization to AS differs significantly among patients sensitized and not to DP (13.43% vs. 3.80%; p=0.019). The higher prevalence is mainly due to cross-reactivity with Der p10 (OR=8.86; 95% CI=4.33-40.74; p=0.0001). Currently, the sensitization to AS seems to have no clinical relevance in the pediatric population.

Anisakis simplex; Dermatophagoides pteronyssinus; prevalence; sensitization; allergy

Table of Content: Vol. 49 (No. 6) 2017 November

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