Food protein-induced enterocolitis syndrome in children: what’s known? What’s new?

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Authors Information

Department of Pediatrics, G. D'Annunzio University, Chieti, Italy


Published online: 24 November 2017
Accepted: 8 November 2017
Received: 11 July 2017


Food protein-induced enterocolitis syndrome (FPIES) is an under-recognized and frequently misdiagnosed non-IgE mediated food allergy syndrome. Affected in-fants show gastrointestinal symptoms few hours after ingestion of the incriminating food. Pathophysiology of FPIES has not yet been clearly defined and needs further characterization. The common allergy tests are not helpful for this disor-der and tests for food specific IgE are usually negative. A diagnostic oral food challenge (OFC) is the method to confirm the diagnosis of FPIES. This review summarizes what is known about epidemiology, pathophysiology, clinical charac-teristics and diagnosis and what’s new about therapeutic options of FPIES.

food protein-induced enterocolitis syndrome; children; pathophysiology; diagno-sis; management

Table of Content: Vol. 50 (No. 3) 2018 May

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