Fecal microbiota profile in atopic asthmatic adult patients
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Authors Information
1 Department of allergy and clinical immunology, Faculty of medicine, Ain Shams University, Cairo, Egypt
2 Department of clinical pathology, Faculty of medicine, Ain Shams University, Cairo, Egypt
History
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Published online: 15 January 2018
Accepted: 20 November 2017
Received: 25 September 2017
SUMMARY
Background. Studies proposed a link between gut microbiota and airway tract. Objective. Study the diversity and density of gut microbiota in healthy and asthmatic patients. Method. Semi-quantitative stool cultures were performed from fecal samples collected from 80 adult asthmatic patients and 40 healthy individuals. Data on gender, age, dietetic history, clinical examination and inves-tigations as skin prick test and pulmonary function testing were also collected. Results. Lactobacilli were found to be higher among patient group than control group. E. coli density was statistically higher in patient than control group. No significant difference was detected between male and female patients or con-trols. Lactobacilli were statistically more prevalent in stool culture of male cases than that of male controls. No difference was found between female cases and controls. There was no relationship between type of microbial growth and dis-ease related parameters including age, duration of illness, number of allergens and pulmonary function test in cases. Conclusion. Atopic asthma is significantly associated with gut microbiota Lactobacilli and E. coli. It is important to deter-mine the organism involved, to focus on microbiome-driven disease and thera-pies.
