Evaluation of two commercial peach extracts for skin prick testing in the diagnosis of hypersensitivity to lipid transfer protein. A multicenter study
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Authors Information
1Allergology Clinic, Clinica San Carlo, Paderno Dugnano, Milan, Italy
2Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy
3Allergology Clinic, Asl RM 4, S. Paolo Civitavecchia Hospital, Civitavecchia, Italy
4Clinical Pathology U.O.C., Buccheri La Ferla F.B.F. Hospital, Palermo, Italy
5Pathology and Clinical Biochemistry, Magna Graecia University, Catanzaro, Italy
6Allergology and Immunology SOS, Prato-Azienda USL Toscana Centro, Prato, Italy
7Romagna Allergy Unit, Internist Department of Rimini, Rimini, Italy
8Laboratorio Unico Metropolitano, AUSL Bologna, Bologna, Italy
9Allergology OUS, Umberto I Hospital, Siracusa, Italy
10School of Specialization in Allergy and Clinical Immunology, Alma Mater Studiorum, Bologna, Italy
11Allergology UO, District of Marsala, ASP 9, Trapani, Italy
12Allergology UO, ASST Lariana, Como, Italy
13Allergology U.O.S.D., S.S. Filippo e Nicola Hospital, Avezzano, Italy
14Struttura Complessa di Allergologia e Immunologia, ASST GOM, Niguarda, Milan, Italy
15Clinic Immunology U.O.C., Policlinico Umberto Primo, Rome, Italy
16Private Practice, Naples, Italy
17Istituto Dermopatico dell'Immacolata, Rome, Italy
18Allergology UOSD, Loreto Crispi, ASL Napoli 1 Centro, Naples, Italy
19Immunology and Allergology Unit, Santa Maria degli Angeli Hospital, Pordenone, Italy
20Pediatric First Aid, Pugliese Ciaccio Hospital, Catanzaro, Italy
21Lofarma SpA, R & D, Milan, Italy
History
Published online: 27 April 2020
Accepted: 6 April 2020
Received: 27 February 2020
SUMMARY
The clinical usefulness of two commercial peach extracts for SPT (by Lofarma SpA and ALK-Abellò, respectively) was compared in a multicenter study carried out in Italy. Peach allergic patients were tested with the two extracts in parallel and underwent the detection of IgE specific for all three peach allergens currently available (Pru p 1, Pru p 3, and Pru p4, respectively). The two extracts were almost identical in terms of sensitivity and specificity, being able to detect virtually all patients sensitized to stable peach allergens (lipid transfer protein [LTP] and, presumably, peamaclein) but scoring negative in patients exclusively sensitive to labile allergens (either PR-10 and/or profilin). Thus, the two extracts represent an excellent tool to carry out a preliminary component-resolved diagnosis of peach allergy at the first patient visit.
