The diverse roles of T cell subsets in asthma

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Authors Information

1Unit of Allergy and Clinical Immunology, University Hospital Center of Coimbra, Coimbra, Portugal
2Institute of Immunology, School of Medicine, University of Coimbra, Coimbra, Portugal
3Coimbra Institute for Clinical and Biomedical Research (iCBR), School of Medicine, University of Coimbra, Portugal
4Hospital CUF Coimbra, Coimbra, Portugal
5Department of Biomedical Sciences and Medicine, University of Algarve, Portugal


Published online: 13 November 2020
Accepted: 26 October 2020
Received: 05 October 2020


T cells are coordinators of the immune response and have been shown to play a central role in the pathophysiology of asthma. A good understanding of the T cells functions in asthma is important for therapeutic reasons, in particular for the choice of biological treatments in severe asthma. Although classically considered a Th2 disease, it is now clear that other types of T cells contribute for the pathophysiology and the heterogeneity of asthma. We here review how the different subsets of T cells are involved in the different phenotypes/endotypes of asthma and how this may influence the treatment of the disease.

Asthma; T cells; regulatory T cells; asthma endotypes; asthma biomarkers.

Table of Content: Vol. 53 (No. 5) 2021 September

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