2.3
2022

Prevalence of allergic bronchopulmonary aspergillosis in cystic fibrosis patients using two different diagnostic criteria

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Authors Information

1Department of Medical Mycology, School of medicine, Mazandaran University of Medical Sciences, Sari, Iran
2Paediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shaheed Beheshti University of Medical Sciences, Tehran, Iran
3Biostatistics Department, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
4Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shaheed Beheshti University of Medical Sciences, Tehran, Iran
5Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran

History

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Published online: 30 October 2019
Accepted: 30 October 2019
Received: 7 October 2019

SUMMARY

Objective. There are different diagnostic criteria for the diagnosis of Allergic bronchopulmonary aspergillosis (ABPA) in CF patients. In this present study we evaluated the prevalence of ABPA in Iranian CF patients by two more usual diagnostic criteria as ISHAM working criteria (A) and CF Foundation Consensus Conference criteria (B). Methods. Eighty-six CF patients were included in the study. All CF patients underwent for Aspergillus skin prick test (AST), Aspergillus-specific IgE (sIgEAf) and Aspergillus-specific IgG (sIgGAf), total IgE. The ABPA prevalence was estimated by two diagnostic criteria, (A) and (B) and compared. Results. The frequency of positive AST, total IgE, sIgEAf and sIgGAf were 47 (54.6%), 9 (10.5%), 42 (48.8%) and 67 (77.9%), respectively. The obtained rate of ABPA prevalence (10.5%) was identical in two diagnostic criteria A and B (kappa value of 1.000). Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence.

KEY WORDS
Cystic Fibrosis (CF); allergic bronchopulmonary, Aspergillosis (ABPA); diagnostic criteria; Aspergillus sensitization; prevalence

Table of Content: Vol. 52 (No. 4) 2020 July

European Annals of Allergy and Clinical Immunology ISSN 1764-1489 | © 2024