Pollen-induced asthma: diagnostic and therapeutic implications
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Authors Information
1Allergy and Immunology Unit, San Giovanni di Dio Hospital, USL Toscana Centro, Florence, Italy
2Allergy Unit, Casa della Salute di Scilla, Scilla, Reggio Calabria, Italy
3Pulmonology Unit, ASST Santi Paolo Carlo, Milan, Italy
4Pulmonology Unit, ASST Rhodense, Garbagnate Milanese Hospital, Milan, Italy
5Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Italy
6Allergy Unit, Department of Internal Medicine, University Hospital delle Marche, Ancona, Italy
7Allergology and Pulmonology Unit, Provincial Outpatient Center of Palermo, Palermo, Italy
8Allergy Clinical Immunology and Rheumatology Unit, ASST Carlo Poma, Mantua, Italy
9Former Head of Pneumology and Chief of the Department of Medicine and Rehabilitation, Guido Salvini Hospital-ASST
Rhodense, Garbagnate Milanese, Milan, Italy
*Joint first co-authorship
**Joint senior co-authorship
History
Published: 02 September 2025
Accepted: 14 July 2025
Received: 03 April 2025
SUMMARY
Evidence supports the hypothesis of pollen-induced asthma as a specific asthma phenotype, with defined clinical features and tailored pathways for its clinical management.
The probability of diagnosis varies significantly in the pollen season, in which allergic patients are symptomatic, as compared to asymptomatic periods outside the pollen season. In this context, a novel diagnostic scheme for pollen-induced asthma has been developed.
Pollen exposure is the key risk factor for symptoms and exacerbations. Therefore, we proposed a therapeutic algorithm for pollen-induced asthma based on a risk stratification model that considers the medical history of the patients and the measurement of objective markers, allowing a tailored therapeutic approach.
