Pollen-induced asthma: a specific pheno-endotype of disease?
Show more: Authors information and Publication history
Authors Information
1Allergy and Immunology Unit, San Giovanni di Dio Hospital, USL Toscana Centro, Florence, Italy
2Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Italy
3Allergy Unit, Department of Internal Medicine, University Hospital delle Marche, Ancona, Italy
4Pulmonology Unit, ASST Santi Paolo Carlo, Milan, Italy
5Pulmonology Unit, ASST Rhodense, Garbagnate Milanese Hospital, Milan, Italy
6Allergy Unit, Casa della Salute di Scilla, Reggio Calabria, Italy
7Allergology and Pulmonology Unit, Provincial Outpatient Center of Palermo, Palermo, Italy
8Former Head of Pneumology and Chief of the Department of Medicine and Rehabilitation, Guido Salvini Hospital‐ASST Rhodense, Garbagnate Milanese, Milan, Italy
9Allergy Clinical Immunology and Rheumatology Unit, ASST Carlo Poma, Mantua, Italy
History
Published: 09 May 2025
Accepted: 30 April 2025
Received: 19 February 2025
SUMMARY
Asthma is a heterogeneous syndrome with a significant social and economic impact. While the knowledge of pheno-endotypes has advanced in severe asthma, little attention has been paid to the phenotypes of mild-moderate asthma. Along this line, a systematic review of the current literature on pollen-induced asthma was carried out, targeting the question whether it can be considered a specific phenotype of disease, with a focus on the role of pollen and its interplay with asthma. This article reports the first part of the review, which covered background information on the multiple atmospheric and environmental factors affecting pollen concentration, the molecular bases of pollen-induced allergenicity and the pathogenic effector circuits that sustain and amplify inflammatory signals in response to allergens in sensitized subjects.
