Hyperlipidemia in association with pro-inflammatory cytokines among chronic spontaneous urticaria: case-control study

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Authors Information

1 Department of Internal Medicine, Allergy and Clinical immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt


Published online: 31 July 2018
Accepted: 28 May 2018
Received: 16 March 2017


Chronic spontaneous urticaria (CSU) is a disorder characterized by recurrent transient itchy wheels of 6 weeks duration or longer. The cause cannot be pinpointed in about 40% of patients. To elucidate the possible association between CSU and hyperlipidemia, 40 CSU patients and 40 group matched healthy individuals were assessed for hyperlipidemia. Data on history, urticaria activity score (UAS-7), physical examination and routine laboratory investigations including (serum IL6 and TNF alpha) were recorded. Statistically significant increase of serum cholesterol, triglycerides (TG), low density lipoprotein (LDL), IL6, TNFalpha and decrease of high density lipoprotein (HDL) was found in CSU in comparison to control group. Regarding the different disease variables, both TG and cholesterol were positively correlated with duration of illness, urticaria score and TNF alpha. Serum LDL detected significant had a positive correlation with duration of illness, urticaria score, CRP and TNF alpha, while serum HDL detected had a significant negative correlation with TNF alpha. IL6 and TNFalpha associated systemic inflammation could be a common pathogenic mechanism of CSU and hyperlipidemia. Patients with CSU should be evaluated for hyperlipidemia.

chronic spontaneous urticaria; hyperlipidemia; IL6; lipid profile; TNFalpha

Table of Content: Vol. 50 (No. 6) 2018 November

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