2.3
2022

House dust mite allergy and shrimp allergy: a complex interaction

Show more: Authors information and Publication history
Authors Information

Show more: Author information and Publication history 1Allergology Clinic, San Carlo Clinic, Paderno Dugnano (MI), Italy
2UOC of Clinical Pathology, Buccheri La Ferla F.B.F. Hospital, Palermo, Italy
3Allergy Unit, Immacolata Dermopathic Institute, IDI-IRCCS, Rome, Italy
4SSD of Immunology and Allergology, S. Maria degli Angeli Hospital, Pordenone, Italy
5Complex Structure of Allergology and Immunology, ASST GOM Niguarda, Milan, Italy
6Department of Laboratory Medicine, ASST GOM Niguarda, Milan, Italy
7Operative Unit of Internal Medicine Rimini, Allergology Clinic, Azienda Sanitaria Romagna, Rimini, Italy
8LUM AUSL, Bologna, Italy
9Allergology Service, Beato Palazzolo Nursing Home, Bergamo, Italy
10Laboratory Medicine Service, ASST Bergamo Ovest, Bergamo, Italy
11UOC of Allergology and Immnology, Lecce POV Fazzi ASL Clinic, Lecce, Italy
12UOSD of Allergology, S.S. Filippo e Nicola Hospital, Avezzano (AQ), Italy
13Allergology Service, Scilla's Nursing Home, Scilla (RC), Italy
14 Allergology Service, University Hospital A. Gemelli Foundation, Rome, Italy
15General Pathology Institute, University Hospital A. Gemelli Foundation, Rome, Italy
16IRCCS Ca' Granda Foundation, Maggiore Policlinico Hospital, Pediatric Area, Milan, Italy
17Allergology Service, UOC Internal Medicine, S. Spirito and Nuovo Regina Margherita Hospital Center, Rome, Italy
18S Laboratory Allergology Service, UOC Clinical Pathology, S. Filippo Neri Hospital, Rome, Italy
19Allergology Unit, Internal Medicine, Faenza Hospital, Faenza (RA), Italy
20Allergic Diseases Center Bonsignori, Biomedicine and Molecular Immunology Institute, CNR, Palermo, Italy
21Pediatric Emergency Room, Ciaccio Apulian Hospital Company, Catanzaro, Italy
22Pathology and Biochemistry Clinic, Magna Graecia University, Catanzaro, Italy
23A. Mirri Experimental Zooprophylactic Sicily's Institute, Palermo, Italy

History

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Published online: 8 October 2019
Accepted: 27 July 2019
Received: 08 July 2019

SUMMARY

Background and objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic controls not sensitized to HDM. Results. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p < 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p < 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p < 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin. Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.

KEY WORDS
Food allergy; peach allergy; lipid transfer protein; SPT; diagnosis.

Table of Content: Vol. 52 (No. 5) 2020 September

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