Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticariaL. de Montjoye email@example.com,2, A-S. Darrigade1, A. Giménez-Arnau3, A. Herman1,2,
L. Dumoutier4, M. Baeck1,2Show more: Authors information and Publication history
Department of Dermatology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium2
Institute of Experimental and Clinical Research, Pneumology, ENT and Dermatology Pole, Université catholique de Louvain, Brussels, Belgium3
Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain4
de Duve Institute, Université catholique de Louvain, Brussels, BelgiumHistory
Published online: 22 February 2021
Accepted: 21 January 2020
Received: 17 January 2020
Biomarkers of disease activity/severity and criteria of autoimmune chronic spontaneous urticaria (CSU) are still a matter of debate. Objective.
To investigate possible correlations between clinical and biological markers and their associations with: 1) disease activity, 2) resistance to H1-antihistamines, 3) autoimmunity and 4) autologous serum skin test (ASST) in patients with CSU. To also analyze biological parameter modifications in patients with CSU treated with omalizumab. Materials and methods.
Disease activity, H1-antihistamines response and presence of concomitant autoimmune disease were prospectively recorded in 95 patients with CSU. For 60 of them, ASST was performed. Broad biological analysis were performed. Results.
C-reactive protein (CRP) serum levels were higher in H1-antihistamines unresponders (p < 0.0001) and in more active diseases (p = 0.033). D-dimer plasma levels were higher in H1-antihistamines unresponders (p = 0.008) and in patients with autoimmune status (concomitant autoimmune disease and/or with autoantibodies) (p = 0.016). Total immunoglobuline E (IgE) serum level was lower in patients with positive ASST. Blood basophil counts were lower in patients with CSU and especially in H1-antihistamines unresponders (p = 0.023), in patients with more active disease (p = 0.023), with positive ASST (p = 0.001), and with autoimmune status (p = 0.057). Conversely, under omalizumab, a decrease of CRP (p = 0.0038) and D-dimer serum/plasma levels (p = 0.0002) and an increase of blood basophil counts (p = 0.0023) and total IgE serum levels (p = 0.0007) were observed. Conclusions.
This study brings additional evidences of interest to investigate IgE, D-dimer serum/plasma levels and basophil blood counts in patients with CSU as they could be correlated to disease activity, response to treatmentand/or autoimmunity.Key words
Chronic spontaneous urticaria; blood basophil count; IgE; autoimmunity; autologous serum skin test.
Cite this article as:
de Montjoye L, Darrigade A-S, Giménez-Arnau A, Herman A, Dumoutier L, Baeck M, Correlations between disease activity, autoimmunity and biological parameters in patientswith chronic spontaneous urticaria, Eur Ann Allergy Clin Immunol 2021;53(2):55-66. doi:10.23822/EurAnnACI.1764-1489.132.