Urticaria and coronavirus infection: a lesson from SARS-CoV-2 pandemic

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Authors Information

1Division of Haematology, Department of Human Pathology in Adulthood and Childhood Gaetano Barresi, University of Messina, Messina, Italy
2COVID Centre AOU Policlinic G. Martino, Messina, Italy
3Allergology Clinic, Clinica San Carlo, Paderno Dugnano, Milan, Italy
4Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
5Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, Messina, Italy


Published online: 22 February 2021
Accepted: 05 October 2020
Received: 18 June 2020


Urticaria is a condition involving both skin and mucosal tissues characterizedby the presence of wheals and/or angioedema. The acute form hasbeen related to allergic reactions to drugs or foods, interaction with chemicals, or infections. We reviewed the association of urticaria with coronavirusinfections.This review was carried out by the use of two searchengines for published original articles, employing two key terms correlatedto urticaria and viruses: “urticaria” and one term linked to each virus.Theresearch of the relationships between SARS-CoV-2 and urticaria produced18 papers (including a total of 114 cases). Surprisingly, the search for casesof urticaria in patients with SARS-CoV or MERS produced no results. Wetried to interpret this discrepancy and attempted to analyze the possiblepathogenesis of urticaria lesions in SARS-CoV-2.

Urticaria; allergy; SARS-CoV-2; COVID-19; MERS-CoV; SARS-CoV; viral infection.

Table of Content: Vol. 53 (No. 2) 2021 March

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