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Contents »

Cost-effectiveness analysis of grass pollen specific immunotherapy in children with allergic rhinitis compared to the standard of care symptomatic treatment in Portugal


M. Farraia mariana.farraia@gmail.com1,2,3, I. Paciência1,2, F. Castro Mendes1,2,3, J. Cavaleiro Rufo1,2, L. Delgado3,4, A. Moreira1,2,3,5

Show more: Authors information and Publication history

Doi
10.23822/EurAnnACI.1764-1489.240

Summary
Background. Cost-effectiveness studies evaluating allergen immunotherapy (AIT) in children are scarce. We aim to compare the cost-effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) against standard-of-care (SOC) treatment in children with grass pollen allergic rhinitis. Methods. We created a Markov model to compare the three strategies over a 10-year horizon. SOC was the reference to calculate the incremental cost-effectiveness ratio (ICER). Deterministic and probabilistic sensitivity analysis were used to assess models' uncertainty. Results. We obtained an ICER of € 12,605  and € 6,318 for SLIT and SCIT, respectively. In sensitivity analysis, SCIT was more cost-effective than SLIT. Conclusions. AIT is cost-effective in children with grass pollen allergic rhinitis, especially for the subcutaneous route.

Key words
Allergen immunotherapy; allergic rhinitis; asthma; children; cost-effectiveness; grass pollen; Markov model; subcutaneous immunotherapy; sublingual immunotherapy.

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