Pru p 3 sublingual immunotherapy ultra-rush protocol is safe and clinically effective

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Authors Information

1Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
2Clinical Immunology, Faculty of Medicine, University of Coimbra, Portugal
3Institute of Immunology, Faculty of Medicine, University of Coimbra, Portugal
4Faculty of Medicine, University of Coimbra, Portugal


Published online: 08 July 2019
Accepted: 29 April 2019
Received: 23 January 2019


Introduction. Sublingual immunotherapy (SLIT) with Pru p 3 can prevent severe allergic reactions to LTP-containing foods but the standard initiation protocol is time-consuming. Aim. Establish the safety of a novel ultra-rush initiation protocol for SLIT with Pru p 3. Methods. Prospective study comparing the side effects of the standard vs novel ultra-rush initiation protocols of SLIT with Pru p 3 in patients with anaphylaxis to LTP. Results. Fifteen patients were included (standard initiation, 5; ultra-rush initiation, 10), 80% females. All patients had oropharyngeal pruritus during initiation, 80% with spontaneous recovery, but no other gastro-intestinal, respiratory, cutaneous or systemic side effects occurred in any patient of both groups. Conclusion. The novel ultra-rush protocol halved the build-up time without increasing side effects.

LTP syndrome; peach allergy; Pru p 3; sublingual immunotherapy; ultra-rush protocol

Table of Content: Vol. 51 (No. 5) 2019 September

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