Evolution of Api m10 specific IgE and IgG4 after one year of bee venom immunotherapy

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Authors Information

1Clinical Immunology Laboratory, Medical School, Molecular Medicine Institute, Lisbon University, Lisbon, Portugal
2Immunoallergology Service, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal
3University Clinic of Immunoallergology, Medical School, University of Lisbon, Lisbon, Portugal


Published online: 15 January 2020
Accepted: 14 January 2020
Received: 15 November 2019


Background. Bee-venom (BV) anaphylaxis can be life-threatening, requiring treatment with BV immunotherapy (bVIT). Different molecular profiles may be associated with different outcomes after bVIT. Methods. In 19 patients with BV anaphylaxis, sensitized both to Api m1 and Api m10, we evaluated sIgE and sIgG4 Api m1 and Api m10 levels before and after 1 year bVIT. Results 7 patients (37%) had higher baseline Api m10 than Api m1 sIgE levels (Api m10 predominant). bVIT reduced sIgE to both components but sIgG4 levels were increased only for Api m1. 5 patients (2 in the Api m10 predominant group) were re-stung without anaphylaxis. Conclusions. Although there was no increase in Api m10 sIgG4 levels after 1 year bVIT, we did not observe relevant differences in other outcomes between patients with predominant Api m1 or Api m10 sensitization.

Anaphylaxis; api m1; api m10; bee venom; venom immunotherapy.

Table of Content: Vol. 52 (No. 4) 2020 July

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