S. A. Dastgheib
, H. Aarafi
, R. Bahrami
, A. Safa
, A. Khosravi-Bonjar
, A. Hashemzehi
, M. Noori-Shadkam
, S. Reza Mirjalili
, S. Salari
, H. Neamatzadeh
1Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pediatrics, Yazd Branch, Islamic Azad University, Yazd, Iran
3Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran
5Department of Pharmacology, Faculty of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7Department of Biology, Science and Arts University, Yazd, Iran
8Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
HistoryPublished: 04 June 2021
Accepted: 04 June 2021
Received: 12 July 2020
Studies evaluating the association of IL-10 polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on -1082G > A, four studies with 622 cases and 603 controls on -819C > T and ten studies with 1480 case and 1462 controls on -592C > A were selected. Overall, there was no a significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10 -1082G > A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10 -1082G > A, -819C > T and -592C > A polymorphisms were not associated with pediatric asthma risk in the global population.
Pediatric athma; Interleukin 10; Cytokine; polymorphism; association.