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Association of IL-10-1082G > A, -819C > T and -592C > A polymorphisms with susceptibility to asthma in children: a systematic reviews and meta-analysis


S. A. Dastgheib1, H. Aarafi dr.hossein.arafi@gmail.com2, R. Bahrami3, S. Setayesh4, M. Noori-Shadkam5, S. Reza Mirjalili5, S. Salari6, M. Zare-Shehneh7, H. Neamatzadeh5,7

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Doi
10.23822/EurAnnACI.1764-1489.219 

Summary

Studies evaluating the association of IL-10 polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on -1082G > A, four studies with 622 cases and 603 controls on -819C > T and ten studies with 1480 case and 1462 controls on -592C > A were selected. Overall, there was no a significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10 -1082G > A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10 -1082G > A, -819C > T and -592C > A polymorphisms were not associated with pediatric asthma risk in the global population.
 
Key words
Pediatric athma; Interleukin 10; Cytokine; polymorphism; association.

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