Interleukin 13 gene polymorphism and susceptibility to asthma: a meta-regression and meta-analysisM. Omraninava1, M. M. Eslami2, S. Aslani3, B. Razi2, D. Imani4, S. Feyzinia Sarafeyzinia@gmail.com5,6Show more: Authors information and Publication history
Department of Infectious Disease, Faculty of Medical Sciences, Islamic Azad University Sari Branch, Sari, Iran2
Department of Hematology, School of Medicine, Tarbiat Modares University, Tehran, Iran3
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran4
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran5
Tuberclousis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran6
Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, IranHistory:
Published online: 16 November 2020
Accepted: 03 November 2020
Received: 29 September 2020
Previously, lots of studies researched the association of Interleukin (IL) 13 gene polymorphisms and the risk of asthma, yielding incongruent outcomes. Objectives.
To resolve the inconsistency among the different studies, we performed the most up-to-date meta-analysis of IL13 gene rs20541
polymorphisms and susceptibility to asthma. Methods.
After a systematic literature search up to September 2020, the pooled Odds Ratio (OR) and their corresponding 95% CI were extracted to determine the association level. Results.
Overall, 45 (containing 10572 cases and 11575 healthy controls) and 31 (containing 10139 cases and 13304 healthy controls) case-control studies for rs20541
polymorphisms, respectively, were retrieved. Pooled analysis indicated statistically significant association of rs20541
with asthma in the overall analysis. According to the subgroup analysis, significant association was detected between rs20541
polymorphism in European population across dominant model, allelic model, and GA vs.
GG model. A strongly significant association between rs20541
polymorphism and asthma risk was identified in Asian population under all genetic models except heterozygote model. There was significant association between rs20541
polymorphism and asthma risk in dominant, allelic and heterozygote models for Caucasians. The rs1800925
SNP was associated with asthma risk in some genetic models for the overall, Asian, and European populations. Conclusions.
polymorphisms of IL13 gene confers a risk factor for asthma in different populations.
Asthma; meta-analysis; IL-13; polymorphism. FULL TEXT