Are currently available biomarkers useful to discriminate CSU patients not controlled by low dose omalizumab maintenance therapy?
R. Asero r.asero@libero.itShow more: Authors information and Publication history Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano Milano, Italy
History:Published online: 19 March 2020
Accepted: 16 March 2020
Received: 29 January 2020
Doihttp://doi.org/10.23822/EurAnnACI.1764-1489.139
SummaryIn patients with chronic spontaneous urticaria (CSU), low dose omalizumab maintenance therapy is effective in about one half of complete, fast responders to the drug. Omalizumab 150 mg/month was given as maintenance therapy to 21 patients with a history of severe CSU showing a complete (UAS7= 0) response to the dose of 300 mg/month. After 2 months of such regimen, patients were divided into controlled (n= 14; UAS7= 0) and not controlled (n= 7; UAS7 > 10) and ESR, CRP, total IgE, and D-dimer were measured. The two groups did not differ in any of the biomarkers considered, nor in disease duration or in pre-treatment UAS7 score. The study confirms that it is possible to halve the dose of Omalizumab without any loss of efficacy in a subgroup of patients with CSU but that none of the currently available biomarkers is able to predict which patients will lose disease control following omalizumab dose reduction.
Key wordsChronic Urticaria; Omalizumab; Biomarkers; IgE; D-dimer
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