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Contents »

Prevalence of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Patients using Two Different Diagnostic Criteria


M. Maleki1 hedayatimt@gmail.com, V. Mortezaee1, M. Hassanzad2, S. A. Mahdaviani2, M. Poorabdollah2, P. Mehrian2, N. Behnampour3, M. S. Mirenayat4, M. Abastabar1,5, M. Tavakoli1,M. T. Hedayati1,5

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.121

Abstract 
Objective. There are different diagnostic criteria for the diagnosis of Allergic bronchopulmonary aspergillosis (ABPA) in CF patients. In this present study we evaluated the prevalence of ABPA in Iranian CF patients by two more usual diagnostic criteria as ISHAM working criteria (A) and CF Foundation Consensus Conference criteria (B). Methods. Eighty six CF patients were included in the study. All CF patients underwent for Aspergillus skin prick test (AST), Aspergillus-specific IgE (sIgEAf) and Aspergillus-specific IgG (sIgGAf), total IgE. The ABPA prevalence was estimated by two diagnostic criteria, (A) and (B) and compared. Results. The frequency of positive AST, total IgE, sIgEAf and sIgGAf were 47 (54.6%), 9 (10.5%), 42 (48.8%) and 67 (77.9%), respectively. The obtained rate of ABPA prevalence (10.5%) was identical in two diagnostic criteria A and B (kappa value of 1.000). Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence.

Key words
cystic fibrosis (CF); allergic bronchopulmonary aspergillosis (ABPA); diagnostic criteria; aspergillus sensitization; prevalence.