Bet v 1 sensitization modulates allergenic molecular immune response

Giorgio Ciprandi¹ gio.cip@libero.it, Michela Silvestri², Angela Pistorio³, Roberta Olcese⁴, Paolo del Barba⁵, Maria Angela Tosca²
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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.73

Summary
Background Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults. This study aimed to evaluate the impact of Bet v 1 sensitization on sensitization pattern in a large sample of children. Methods Serum IgE molecular components were assessed by ISAC method. Sera from 1,205 children, 708 males (58.76%) and 497 females (41.24%), median age 8.61 years (4.93 - 12.54 years) were analyzed. Results A total of 354 PR-10-positive subjects were detected out of 1,205 subjects. Bet v 1 positive children were significantly more frequently sensitized to other molecules belonging to PR-10 family and noteworthy also to other allergenic families than Bet v 1 negative children. Conclusions The present study demonstrates that Bet v 1 sensitization may significantly affect the sensitization pattern in children living in Genoa, a Mediterranean city located in a birch-free area.

Keywords
allergen-specific IgE, Bet v 1, molecular component, pan-allergen, ISAC, serum