Probiotics, prebiotics and food allergy
Joana Filipe Ribeiro
joanafiliperibeiro@gmail.com1, Cláudia Pedrosa
2Show more: Authors information and Publication history1Department of Paediatric, Sousa Martins Hospital, Guarda's Health Local Unit, Guarda, Portugal
2Paediatric Allergy and Pneumology Unit, Department of Paediatric, Vila Nova de Gaia/ spinho Hospital Center, EPE, Vila Nova de Gaia, Portugal
HistoryPublished: 06 December 2023
Accepted: 04 December 2023
Received: 14 June 2023
Doi10.23822/EurAnnACI.1764-1489.319SummaryBackground. The prevalence of food allergy (FA) has increased, a possible consequence of intestinal dysbiosis, environmental or genetic factors. Currently, no formal indications exist for probiotic or prebiotic supplementation in FA. This review aims to analyse the role of probiotics and prebiotics in the prevention and treatment of FA.
Methods. A PubMed/Medline search was carried out on articles published between 2011 and 2021 with the following query: ("Food Hypersensitivity"[Mesh]) AND (("Probiotics"[Mesh]) OR ("Prebiotics"[Mesh])). Subsequently, the titles and abstracts were analysed and selected according to established criteria. After full reading of these articles, 54 were included and a narrative review was performed.
Results. The review was structured in the following sections: i) Cow's Milk Proteins Allergy (CMA), ii) Food Allergy to Peanuts and iii) Prevention of Food Allergy. In CMA, several studies have supported the benefits of extensively hydrolysed casein formula supplemented with
Lactobacillus Rhamnosus GG in the earlier acquisition of tolerance to cow's milk proteins, resolution of gastrointestinal symptoms and prevention of other allergic manifestations. In peanut oral immunotherapy (OI), supplementation with
Lactobacillus Rhamnosus CGMCC 1.3724 seems to have a favourable impact in inducing a sustained desensitization response. Regarding the use of probiotics in the prevention of FA, this assumption lacks robust scientific evidence in order to confirm the effectiveness. Current evidence supports the use of oligosaccharides from breast milk in the first months of life for preventing atopic dermatitis, FA and asthma.
Conclusions. The potential of probiotics to be used as therapeutic adjuvants in CMA and peanut OI is promising. However, there is inconsistency regarding the type of probiotic, the dose and duration of supplementation. Further studies are needed to clarify the role of probiotics and prebiotics in FA.
Key wordsProbiotics; prebiotics; food allergy; dysbiosis; microbiota.
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