V. Grossi
, M. Severino
, A. Massolo
, M. Infantino
, F. Laureti
, D. Macchia
, E. Meucci
, E. Francescato
, B. Pantera
, A. Ebbli
, F. Fumagalli
, B. Lari
, A. Perri
, I. Liotti
, G. Ciotta
, G. Terenzi
, S. V. Valeva
, M. Consolati
, T. Folgore
, M. Manfredi
1Immunology and Allergy Laboratory Unit, San Giovanni di Dio Hospital, Florence, Italy
2Anallergo, Scarperia e San Piero, Florence, Italy
3Ethology Unit, Department of Biology, University of Pisa, Pisa, Italy
4Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
5UMR CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, Besançon, France
6Medical and Scientific Affairs, Immuno Diagnostics, Thermo Fisher Scientific, Monza, Italy
7Allergology and Clinical Immunology Unit, San Giovanni di Dio Hospital, Florence, Italy
8Entomon, S.R.L, Florence, Italy
9Immunohematology Transfusion Medicine and Allergology Unit, San Paolo, Hospital, Savona, Italy
10Allergy Clinic, ASL 2 Savona, Savona, Italy
HistoryPublished: 13 December 2022
Accepted: 05 December 2022
Received: 05 October 2022
(VVN), commonly known as Asian wasp because endemic in Asia, represents an alien species in Europe. VVN can induce allergic reactions similar to those caused by other
and deaths after VVN stings, presumably due to fatal allergic reactions, were reported. In the treatment of
venom hypersensitivity, specific immunotherapy (VIT) is highly effective, and the vaccine allergen-specificity plays a crucial role. Currently, there is no specific available VIT for VVN, so VVN stung patients with severe systemic reactions are treated with
(Vspp) venom. It is also relevant to assess if patients stung by VVN and showing allergic reactions could be treated with the
(VC) and Vspp, or if they need the specific VIT with VVN venom extract. Our results suggested that both Vspp and VC venoms were able to inhibit the specific IgE for VVN, although the VC venom, compared to the venom of Vspp showed a higher inhibition.
venoms.