Der p 23 sensitisation in patients with house dust mite respiratory allergy
L. Romero-Sánchez firstname.lastname@example.org
, A. Otero1
, M. González-Rivas1
, S. Lojo2
, A. González-Quintela3
, C. Vidal1Show more: Authors information and Publication history
Department of Allergy, Faculty of Medicine, Complejo Hospitalario Universitario de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain 2
Department of Biochemistry, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain 3
Department of Medicine, Faculty of Medicine, Complejo Hospitalario Universitario de Santiago, University of Santiago de Compostela, Spain
Published: 27 July 2022
Accepted: 27 July 2022
Received: 26 April 2022 March 2021
The sensitization profile of patients allergic to house dust mites (HDM) and its molecular diagnosis may determine treatment and evolution of the disease. The present study investigates the prevalence of Der p 23 sensitization and its relation to asthma in a population of HDM-allergic patients. Methods.
We conducted a cross-sectional study of 891 patients with HDM allergy with symptoms of rhinitis and 52.1% of them with asthma. Total and specific IgE (sIgE) was measured against Dermatophagoides pteronyssinus
and its molecular components (Der p 1, Der p 2 and Der p 23) and the storage mite Lepidoglyphus destructor
using ImmunoCAP. Prevalence of sensitization and levels of sIgE were analysed according to asthma diagnosis and asthma severity. Results.
Der p 23 was the predominant allergen in this population (83.7%) but IgE levels were lower than those of sIgE to Der p 1 and Der p 2. A good correlation was found between sIgE to Der p 23 and the other allergens. A total of 8.2% patients were monosensitized to Der p 23. Asthma was more frequent in patients with positive sIgE against Der p 23 than in patients without this sensitization (52.8% vs
42.8%, p = 0.027). A tendency to increase both total IgE and sIgE was observed in relation to the severity of asthma from intermittent mild asthma to persistent moderate asthma but a substantial decrease in total IgE and sIgE was detected in more severe asthmatics. Conclusions.
Der p 23 might be a prevalent allergen in regions with high rates of HDM exposure. Even though sIgE levels against this allergen are usually low, its presence could increase the risk of asthma. Key words
Allergy; Der p 23; house dust mite; asthma; Dermatophagoides pteronyssinus
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