Department of Pediatric Gastroenterology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran2
Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran3
Department of Immunology and Allergy, Academic Center for Education, Culture, and Research (ACECR), Tehran, Iran4
Department of Clinical Pathology, Atieh Hospital, Tehran, Iran5
Department of Pediatric Gastroenterology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran6
Division of Pediatric Gastroenterology, Ali-Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran7
Bahrami Children Hospital, Tehran University of Medical Sciences, Roshan Azma Pathobiology Laboratory, Pediatric Gastro- Enterology Research Center, Tehran, IranHistory:
Published online: 22 February 2021
Accepted: 11 May 2020
Received: 26 July 2019
Eosinophilic esophagitis (EoE) is a chronic allergen/immune-mediated disease leading to esophageal dysfunction. Food allergens play critical roles in the pathogenesis and treatmentof EoE via different mechanisms. This study aimed to present the characteristics and evaluate the ability of skin prick test (SPT), skin prick to prick test (SPP) (IgE-mediated), and atopic patch test (APT) (cell-mediated) individually or simultaneously to diagnose food allergy in patients suffering from EoE. This prospective study was conducted on 58 patients with EoE. Seven patients (12.1%) were positive to only one, 3 (5.2%) were simultaneously positive to two, and 32 (55.2%) were simultaneously positive to three tests. Single and double sensitizations were totally 10.4% in IgE-mediated reactions, while 36.5% in cell-mediated reactions. In contrast, poly sensitization (> 2 allergens) was 51.7% in IgE-mediated tests and 20.7% in the cell-mediated test. Multiple sensitization findings showed egg white, milk, yolk, and soy were the most frequent allergens. Our findings indicate that EoE is early onset and associated with multiple food sensitizations, particularly via IgE-mediated mechanisms. These immune-mediated responses encompass both IgE-mediated (SPT and SPP) and cell-mediated (APT) reactions simultaneously not individually. Therefore, employing multiple assays may strengthen the diagnosis of food sensitization.
Eosinophilic esophagitis; skin prick test; prick to prick test; atopic patch test; IgE; non-IgE-mediated food allergy.
Cite article as:
Yousefi A, Nasehi S, Arshi S, Nabavi M, Bemanian MH, S. Shokri S, Seif F, Khoshmirsafa M, Saeedi Y, Sadeghian M, Talachian E, Rajabian B, Mahjoub F, Fallahpour M, Assessment of IgE- and cell-mediated immunity in pediatric patients with eosinophilic esophagitis, Eur Ann Allergy Clin Immunol 2021;53(2):86-90. doi:10.23822/EurAnnACI.1764-1489.154.