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Clinical trial to assess tolerability and subrogate efficacy effects of an abbreviated schedule with house dust mites mixture subcutaneous immunotherapy


I. Antépara1, A. Roger2, N. Bernedo3, R. Lleonart4, F. Rodríguez5, B. Madariaga6, J. A. Asturias6, L. Begoña6, A. Martínez6, A. Landeta6, M. C. Gómez-Fernández maricruz.gomez@roxall.es6

Show more: Authors information and Publication history

Doi
10.23822/EurAnnACI.1764-1489.140

Summary
Objective.
To evaluate the tolerability and efficacy of Dermatophagoides pteronyssinus/Dermatophagoidesfarinae mixture subcutaneous immunotherapy (SCIT). Methods. Patientsreceived an abbreviated build-up schedule. The aims were: number, percentage, and severityof adverse reactions. Secondary outcomes included: changes in immunoglobulin titers and changes in dose-response skin prick tests. Results. Out of 289 administrations, 17% elicitedany clinically relevant adverse reaction. Most of them were local reactions (LR) (9.4%) and the rest (7.6%) were systemic. Significant increases in sIgG and sIgG4 were detectedin serum samples. Cutaneous reactivity decreased significantly. Conclusions. SCIT withhouse dust mites mixture of ROXALL Medicina España S.A. seems to have an acceptabletolerability profile, induces blocking IgG and decreases skin reactivity.

Key words
House dust mites; DPT/DF mixture; subcutaneous immunotherapy; rhinoconjunctivitis; abbreviated schedule.

Cite article as:
Antépara I, Roger A, Bernedo N, Lleonart R, Rodríguez F, Madariaga B, Asturias JA, Begoña L, Martínez A, Landeta A, Gómez-Fernández MC,Clinical trial to assess tolerability and subrogate efficacy effects of an abbreviated schedule with house dust mites mixture subcutaneous immunotherapy, Eur Ann Allergy Clin Immunol 2021;53(2):67-74. doi:10.23822/EurAnnACI.1764-1489.140.

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