Allergology Clinic, San Carlo Clinic, Paderno Dugnano (MI), Italy2
UOC of Clinical Pathology, Buccheri La Ferla F.B.F. Hospital, Palermo, Italy3
Allergy Unit, Immacolata Dermopathic Institute, IDI-IRCCS, Rome, Italy4
SSD of Immunology and Allergology, S. Maria degli Angeli Hospital, Pordenone, Italy5
Complex Structure of Allergology and Immunology, ASST GOM Niguarda, Milan, Italy6
Department of Laboratory Medicine, ASST GOM Niguarda, Milan, Italy7
Operative Unit of Internal Medicine Rimini, Allergology Clinic, Azienda Sanitaria Romagna, Rimini, Italy8
LUM AUSL, Bologna, Italy9
Allergology Service, Beato Palazzolo Nursing Home, Bergamo, Italy10
Laboratory Medicine Service, ASST Bergamo Ovest, Bergamo, Italy11
UOC of Allergology and Immnology, Lecce POV Fazzi ASL Clinic, Lecce, Italy12
UOSD of Allergology, S.S. Filippo e Nicola Hospital, Avezzano (AQ), Italy13
Allergology Service, Scilla's Nursing Home, Scilla (RC), Italy14
Allergology Service, University Hospital A. Gemelli Foundation, Rome, Italy15
General Pathology Institute, University Hospital A. Gemelli Foundation, Rome, Italy16
IRCCS Ca' Granda Foundation, Maggiore Policlinico Hospital, Pediatric Area, Milan, Italy17
Allergology Service, UOC Internal Medicine, S. Spirito and Nuovo Regina Margherita Hospital Center, Rome, Italy18
S Laboratory Allergology Service, UOC Clinical Pathology, S. Filippo Neri Hospital, Rome, Italy19
Allergology Unit, Internal Medicine, Faenza Hospital, Faenza (RA), Italy20
Allergic Diseases Center Bonsignori, Biomedicine and Molecular Immunology Institute, CNR, Palermo, Italy21
Pediatric Emergency Room, Ciaccio Apulian Hospital Company, Catanzaro, Italy22
Pathology and Biochemistry Clinic, Magna Graecia University, Catanzaro, Italy23
A. Mirri Experimental Zooprophylactic Sicily's Institute, Palermo, ItalyHistory
Published online: 8 October 2019
Accepted: 27 July 2019
Received: 08 July 2019
. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study.
. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic controls not sensitized to HDM.
. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p < 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p < 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p < 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin.
. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.
Food allergy; peach allergy; lipid transfer protein; SPT; diagnosis.