Two case reports of delayed-allergic reactions to clindamycin confirmed with a positive lymphocyte transformation test
F. Vílchez-Sánchez1 franvilsan@gmail.com, J. Domínguez-Ortega1,3, M. González Muñoz2, D. Loli-Ausejo1, R. Heredia-Revuelto1, A. Fiandor Román1, S. Quirce1,3Show more: Authors information and Publication history1Department of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain
2Department of Immunology, Hospital La Paz, Madrid, Spain
3CIBER de Enfermedades Respiratorias, Ciberes, Madrid, Spain
History:
Published online: 29 October 2019
Accepted: 06 September 2019
Received: 23 July 2019
Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.117
Abstract
Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.
Key words
clindamycin; allergy; delayed reaction; lymphocyte transformation test; diagnosis
Cite this article as:
Vílchez-Sánchez F, Domínguez-Ortega J, González Muñoz M, Loli-Ausejo D, Heredia-Revuelto R, Fiandor Román A, Quirce S, Two case reports of delayed-allergic reactions to clindamycin confirmed with a positive lymphocyte transformation test, Eur Ann Allergy Clin Immunol. 2020;52(2): 91-93. doi: 10.23822/EurAnnACI.1764-1489.117
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