1Department of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain
2Department of Immunology, Hospital La Paz, Madrid, Spain
3CIBER de Enfermedades Respiratorias, Ciberes, Madrid, Spain
Published online: 29 October 2019
Accepted: 06 September 2019
Received: 23 July 2019
Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.