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Table of Contents »

Isoforms of Group 1 Allergens from a Tropical/Subtropical Para Grass (Urochloa mutica) Display Different Levels of IgE Reactivity and Cross-reactivity


S. Dhammachat1,2, K. Somkid2,3, S. Piboonpocanun4, O. Reamtong5, P. Pacharn6, C. Bunnag7, M. Nakano8, W. Songnuan wisuwat.son@mahidol.edu2,9

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.95

Abstract
Group 1 grass pollen allergens, or beta-expansins, are the most important major allergens from tropical/subtropical grasses. This study aimed to investigate the sequence similarity, and immunoreactivity of group 1 allergens from Para grass (Urochloa mutica). Three isoforms (Uro m 1.01, Uro m 1.02, and Uro m 1.03) were cloned from cDNA of Para grass pollen. The acidic-neutral isoforms rUro m 1.01 and rUro m 1.02 could effectively inhibited beta-expansins in pollen extract of Bermuda and Johnson grasses, suggesting that these isoforms could be major cross-reacting allergens among these grasses. In contrast, the basic isoform rUro m 1.03 had limited IgE reactivity. Thus, group 1 allergens both acidic-neutral and basic isoforms could have markedly different IgE reactivity.

Key words
Para grass pollen, beta-expansins, isoallergens, Uro m 1, recombinant group-1 allergen

Cite this article as:
Dhammachat S, Somkid K, Piboonpocanun S, Reamtong O, Pacharn P, Bunnag C, Nakano M, Songnuan W. Isoforms of Group 1 Allergens from a Tropical/Subtropical Para Grass (Urochloa mutica) Display different levels of IgE reactivity and cross-reactivity. 2019;51(4):174-185. doi:10.23822/EurAnnACI.1764-1489.95


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