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Table of Contents »

Venom Immunotherapy: a 20-year experience with an ultra-rush protocol (210-min)


J. Cosme joanamcosme@gmail.com1, A. Spínola-Santos1, M.C. Pereira-Santos2,3, M Pereira-Barbosa1,3

Show more: Authors information and Publication history

Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.85

Abstract
Background: Ultra-rush (UR) are induction protocols used in venom immunotherapy (VIT). Objectives: To evaluate the adverse reactions during a 210-minutes UR and determine possible risk factors. Methods: Retrospective study of 129 patients submitted to UR with VIT in the last 20 years. Results: In 114 (88.4%) patients the 101.1 ìg maintenance dose was reached in 210 minutes. Systemic reactions (SR) occurred in 22% of patients (71% mild). There were no severe SR, late reactions or fatalities. Adrenaline was administered in 10% of all UR. The SR were more frequent with honey bee VIT and had greater severity in the patients with a previous severe systemic sting reaction. No significant difference in the risk of SR was found with other demographic, clinical or laboratory factors. There were 5% of large local reactions (LLR), these being more frequent in females. Conclusion: Most SR during UR were mild with no need for adrenaline treatment. The honey bee venom and the severity of the anaphylaxis during the field sting were the only SRLs risk factors for systemic adverse reactions during the UR.

Key-words: Adverse reactions, honey-bee, paper wasp, ultra-rush, wasp.


Cite this article as:
Cosme J, Spínola-Santos A, Pereira-Santos M.C, Pereira-Barbosa M. Venom Immunotherapy: a 20-year experience with an ultra-rush protocol (210-min) . Eur Ann Allergy Clin Immunol. 2019;51(3):122-128. doi:10.23822/EurAnnACI.1764-1489.85

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