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Table of Contents »

Allergic reactions after vaccination: translating guidelines into clinical practice


A. Radice1radiceanna87@gmail.com, G. Carli2, D. Macchia1, A. Farsi2

Show more: Authors information and Publication history

Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.86

Summary
Vaccination represents one of the most powerful medical interventions on global health. Despite being safe, sustainable, and effective against infectious and in some cases also non-infectious diseases, it's nowadays facing general opinion's hesitancy because of a false perceived risk of adverse events. Adverse reactions to vaccines are relatively rare, instead, and those recognizing a hypersensitivity mechanism are even rarer. The purpose of this review is to offer a practical approach to adverse events after vaccination, focusing on immune-mediated reactions with particular regard to their recognition, diagnosis and management. According to clinical features, we propose an algorythm for allergologic work-up, which helps in confirming hypersensitivity to vaccine, nonetheless ensuring access to vaccination. Finally, a screening questionnaire is included, providing criteria for immunisation in specialized care settings.

Keywords
vaccine; vaccination; allergic reactions; anaphylaxis; vaccine hesitancy; vaccine components; desensitization

Cite this article as:
Radice A, Carli G, Macchia D. Allergic reactions after vaccination: translating guidelines into clinical practice. Eur Ann Allergy Clin Immunol. 2019;51(2):51-61. doi:10.23822/EurAnnACI.1764-1489.86

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