Bet v 1 sensitization modulates allergenic molecular immune response
G. Ciprandi1 gio.cip@libero.it, M. Silvestri2, A. Pistorio3, R. Olcese4, P. del Barba5, M. Angela Tosca2.Show more: Authors information and Publication history1 Ospedale Policlinico San Martino, Genoa, Italy
2 Pediatric Pneumology, IRCCS-Istituto Giannina Gaslini, Genoa, Italy
3 Epidemiology and Biostatistics Service, IRCCS-Istituto Giannina Gaslini, Genoa, Italy
4 Pediatric Allergy, IRCCS-Istituto Giannina Gaslini, Genoa, Italy
5 Università Vita Salute San Raffaele, Milan, Italy
Publication History:
Published online: 24 September 2018
Accepted: 31 July 2018
Received: 11 July 2018
Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.73 Summary Background Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults. This study aimed to evaluate the impact of Bet v 1 sensitization on sensitization pattern in a large sample of children.
Methods Serum IgE molecular components were assessed by ISAC method. Sera from 1,205 children, 708 males (58.76%) and 497 females (41.24%), median age 8.61 years (4.93 - 12.54 years) were analyzed.
Results A total of 354 PR-10-positive subjects were detected out of 1,205 subjects. Bet v 1 positive children were significantly more frequently sensitized to other molecules belonging to PR-10 family and noteworthy also to other allergenic families than Bet v 1 negative children.
Conclusions The present study demonstrates that Bet v 1 sensitization may significantly affect the sensitization pattern in children living in Genoa, a Mediterranean city located in a birch-free area.
Keywords
allergen-specific IgE, Bet v 1, molecular component, pan-allergen, ISAC, serum
Cite this article as:
Ciprandi G, Silvestri M, Pistorio A, Olcese R, Del Barba P, Tosca M.A. Bet v 1 sensitization modulates allergenic molecular immune response . Eur Ann Allergy Clin Immunol. 2019;51(1):21-31. doi:10.23822/EurAnnACI.1764-1489.73
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