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Table of Contents »

Hypersensitivity to antiretroviral drugs


M.J. Sousa1 mariaj.sousa@gmail.com, S. Cadinha1, M. Mota2, T. Teixeira2, D. Malheiro1, J. P. Moreira da Silva2

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.42

Summary
Background
. Antiretroviral therapy (ART) may be responsible for hypersensitivity reactions varying in severity, clinical manifestations and frequency. Case report. We report the case of a 47-year-old woman with HIV infection who developed a delayed mucocutaneous reaction after treatment with ART. Hypersensitivty reaction (HR) to emtricitabine and tenofovir was considered probable based on positive patch tests (PT) and hypersensitivity reaction to nevirapine was con-firmed by drug provocation test. Discussion. The diagnosis of HR to ART remains a diagnostic challenge, partly due to unknown mechanism and the absence of validated diagnostic tools. Patch testing may represent a useful method for confirming hypersensitivity. Further investigation in this area is required, so that successful management strategies can be offered, preventing loss of potent and viable antiretroviral agents.

Key words
emtricitabine; hypersensitivity; nevirapine; patch tests; tenofovir


Cite this article as:
Sousa M.J, Cadinha S, Mota M, Teixeira T,  Malheiro D, Moreira da Silva J. P. Hypersensitivity to antiretroviral drugs. Eur Ann Allergy Clin Immunol. 2018;50(6):277-280. doi:10.23822/EurAnnACI.1764-1489.42

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