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An atlas of IgE sensitization patterns in different Italian areas. A multicenter, cross-sectional study


E. Scala1 e.scala@idi.it, D. Villalta2, C.G. Uasuf3, P. Pignatti4, L. Pirrotta1, E.C. Guerra1, M. Locanto1, G. Meneguzzi1, M. Giani1, L. Cecchi5, D. Abeni6, R. Asero7

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.67

Summary
Background. The development of recombinant technology supported the allergy diagnostic work-up in the daily clinical practice, representing a useful tool for epidemiological studies. Methods. An atlas of the IgE sensitization profiles found throughout Italy was prepared from a nationwide, multicenter, cross-sectional study. Results. 6052 unselected consecutive individuals, belonging to North-West [NW], North-East [NE], Centre [C], South [S], and Islands subset [Is] were evaluated by means of the ImmunoCAP ISAC test. The top-ranked sensitizations found were Cup a 1 in [C] (58.1%) and [S] (53.6%), Phl p 1 in the North (from 46.1% to 49%), and Cyn d 1 in [Is] (44.2%). High frequency of house dust mite group 2 molecules sensitization was found in [C] (36.9%) and [S] Italy (40.8%), whilst low level of reactivity was recorded in [NW] (20%). Pellitory hypersensitivity was mainly found in [C], [S], and [Is], whilst ragweed Amb a 1 sensitivity was particularly found in [NW] Italy. IgE recognition of PR-10, Profilin, and nsLTP was mutually exclusive in 69.1% of cases, PR-10 reactivity mostly occurring in [NE], Profilin in [NW], and nsLTP molecules recognition mainly recorded in [C] and [S]. Conclusions. Divergent IgE sensitization patterns were found along Italy, possibly linked to the distinct geographical locations, indicating multiplex system IgE analysis as a reliable approach for epidemiological evaluation even in small geographical areas.

Keywords
microarray; PR-10; Profilin; nsLTP; epidemiology


Cite this article as:
Scala E, Villalta D, Uasuf C.G, Pignatti P, Pirrotta L, Guerra E.C, Locanto M, Meneguzzi G, Giani M, Cecchi L, Abeni D, Asero R. An atlas of IgE sensitization patterns in different Italian areas. A multicenter, cross-sectional study . Eur Ann Allergy Clin Immunol. 2018;50(5):217-225. doi:10.23822/EurAnnACI.1764-1489.67

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