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Table of Contents »

Successful treatment of mastocytic anaphylactic episodes with reduction of skin mast cells after anti-IgE therapy

G. Paraskevopoulos, E. Sifnaios, K. Christodoulopoulos, F. Mantopoulou, M. Papakonstantis, D. Sabaziotis

Mastocytosis is a clonal disease derived from hematopoietic bone marrow progenitor cells.
Clinical manifestations of the disease vary greatly depending on tissue involvement. Omalizumab is a recombinant humanized monoclonal anti-IgE antibody licensed in the treatment of asthma with increasing reports of clinical efficiency in other allergic diseases. We describe a case of a patient with mastocytosis responsive clinically and patho-physiologically after anti-IgE treatment.

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