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Table of Contents »

Omalizumab in chronic spontaneous and inducible urticaria: a 9 year retrospective study in Portugal


J. Marcelino1 jlam_1987@sapo.pt, A.C. Costa1, A. Mendes1, E. Alonso1, F. Cabral Duarte1, E. Pedro1, M. Pereira-Barbosa1,2

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.51

Summary
Objective. Describe the safety and long-term use of omalizumab in chronic urticaria (CU), both spontaneous (CSU) and inducible (CIndU). Methods. Retrospective chart-review (2006-15) of CU patients treated with omalizumab for >/= 6 months. Statistical analyses: descriptive statistics, Mann-Whitney, generalized linear models. Results. 23 patients with CSU (3 men), 3 with CIndU (2 men). Generalized linear models showed UAS reduction per omalizumab administration of 16% in CIndU and CSU (both p < 0.001) and UAS7, of 15% in CIndU, and 20% in CSU (both p < 0.001). DLQI score at baseline had a median of 19 (CIndU and CSU) and after omalizumab a median of 0 (in both). Seven CSU patients stopped omalizumab and remain asymptomatic. No side-effects were observed. Conclusion. Omalizumab is safe and efficacious in CU. Stopping omalizumab can be tried, as some patients achieve remission.

Key words
omalizumab; anti-IgE; chronic spontaneous urticaria; chronic inducible urticaria; quality of life


Cite this article as:
Marcelino J, Costa C, Mendes A, Alonso E, Cabral Duarte F, Pedro E, Pereira-Barbosa M. Omalizumab in chronic spontaneous and inducible urticaria: a 9 year retrospective study in Portugal. Eur Ann Allergy Clin Immunol. 2018;50(4):169-176. doi:10.23822/EurAnnACI.1764-1489.51

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