Prevalence, molecular characterization, and clinical relevance of sensitization to Anisakis simplex in children with sensitization and/or allergy to Dermatophagoides pteronyssinus

M.C. Verga¹ vergasa@virgilio.it, R. Pastorino², A. Casani³, F. Inturrisi², C. de Waure², A. Pugliese⁴, I. Dello Iacono⁵

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.26

Summary
Prevalence of the Anisakis Simplex's (AS) sensitization in children sensitized to Dermatophagoides pteronissynus (DP) is not known, neither it is to which percentage it might be due to cross-reactivity. The primary objective of the present retrospective cross-sectional study is to evaluate the prevalence of sensitization to AS in children sensitized or allergic to DP. Secondary outcomes were the prevalence of cross-reactivity and clinical relevance of the condition. The prevalence of sensitization to AS differs significantly among patients sensitized and not to DP (13.43% vs. 3.80%; p=0.019). The higher prevalence is mainly due to cross-reactivity with Der p10 (OR=8.86; 95% CI=4.33-40.74; p=0.0001). Currently, the sensitization to AS seems to have no clinical relevance in the pediatric population.

Key words
Anisakis simplex; Dermatophagoides pteronyssinus; prevalence; sensitization; allergy
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